Efficient Self-Attention Model for Speech Recognition-Based Assistive Robots Control.

Assistive robots are tools that people living with upper body disabilities can leverage to autonomously perform Activities of Daily Living (ADL). Unfortunately, conventional control methods still rely on low-dimensional, easy-to-implement interfaces such as joysticks that tend to be unintuitive and cumbersome to use. In contrast, vocal commands may represent a viable and intuitive alternative.

LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells.

5-lipoxygenase (5-LO), coded by the ALOX5 gene, is expressed in leukocytes and catalyzes the formation of leukotrienes, pro-inflammatory lipid mediators. Leukotrienes are central to immune responses, but are also involved in inflammatory disorders and 5-LO expression is associated with leukemia stem cell survival. It is therefore important to understand mechanisms that control 5-LO expression.

Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5-lipoxygenase and stability in human blood and HepaRG cells.

5-lipoxygenase (5-LO) catalyzes the biosynthesis of leukotrienes, potent lipid mediators involved in inflammatory diseases, and both 5-LO and the leukotrienes are validated therapeutic targets. Caffeic acid phenethyl ester (CAPE) is an effective inhibitor of 5-LO and leukotriene biosynthesis but is susceptible to hydrolysis by esterases. In this study a number of CAPE analogues were synthesized with modifications to the caffeoyl moiety and the replacement of the ester linkage with a ketone.

Voice Control Interface Prototype for Assistive Robots for People Living with Upper Limb Disabilities.

This paper presents a voice control interface prototype for assistive robots aiming to help people living with upper limb disabilities to perform daily activities autonomously. Assistive robotic devices can be used to help people with upper-body disabilities gain more autonomy in their daily life. However, it is very difficult or even impossible for certain users to control the robot with conventional control systems (e.

20-Hydroxy- and 20-carboxy-leukotriene (LT) B downregulate LTB -mediated responses of human neutrophils and eosinophils.

Leukotriene B (LTB ) plays a prominent role in innate immunity as it induces phagocyte recruitment, the release of antimicrobial effectors, and as it potentiates the ingestion and killing of pathogens. In humans, LTB has a short half-life and is rapidly metabolized by leukocytes, notably into 20-OH- and 20-COOH-LTB by neutrophils. Although these LTB metabolites bind to the BLT receptor with high affinity, they activate neutrophils to a much lower extent than LTB .

Identification of Peracetylated Quercetin as a Selective 12-Lipoxygenase Pathway Inhibitor in Human Platelets.

The inflammatory response is necessary for the host's defense against pathogens; however, uncontrolled or unregulated production of eicosanoids has been associated with several types of chronic inflammatory diseases. Thus, it is not surprising that enzymes implicated in the production of eicosanoids have been strategically targeted for potential therapeutic approaches. The 12()-hydroxyeicosatetraenoic acid [12()-HETE] lipid mediator is among inflammatory molecules that are abundantly produced in various diseases and is primarily biosynthesized via the 12()-lipoxygenase pathway.

On the cellular metabolism of the click chemistry probe 19-alkyne arachidonic acid.

Alkyne and azide analogs of natural compounds that can be coupled to sensitive tags by click chemistry are powerful tools to study biological processes. Arachidonic acid (AA) is a FA precursor to biologically active compounds. 19-Alkyne-AA (AA-alk) is a sensitive clickable AA analog; however, its use as a surrogate to study AA metabolism requires further evaluation.

Clicked cinnamic/caffeic esters and amides as radical scavengers and 5-lipoxygenase inhibitors.

5-Lipoxygenase (5-LO) is the key enzyme responsible for the conversion of arachidonic acid to leukotrienes, a class of lipid mediators implicated in inflammatory disorders. In this paper, we describe the design, synthesis, and preliminary activity studies of novel clicked caffeic esters and amides as radical scavengers and 5-LO inhibitors. From known 5-LO inhibitor 3 as a lead, cinnamic esters 8a-h and amides 9a-h as well as caffeic esters 15a-h and amides 16a-h were synthesized by Cu(I)-catalyzed [1,3]-dipolar cycloaddition with the appropriate azide precursors and terminal alkynes.

2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV.

The endocannabinoid 2-AG is highly susceptible to its hydrolysis into AA, which activates neutrophils through de novo LTB(4) biosynthesis, independently of CB activation. In this study, we show that 2-AG and AA stimulate neutrophils to release antimicrobial effectors. Supernatants of neutrophils activated with nanomolar concentrations of 2-AG and AA indeed inhibited the infectivity of HSV-1 and RSV.