Obstructive sleep apnea and early weight loss among adolescents undergoing bariatric surgery.

Background: Little is known regarding obstructive sleep apnea's (OSA's) prevalence or the factors related to OSA remission post-metabolic bariatric surgery (MBS) in adolescents.

Objectives: To identify the baseline OSA prevalence in adolescents with severe obesity and examine factors associated with post-MBS OSA remission.

Setting: Tertiary-care children's hospital.

Ablation of nectin4 binding compromises CD46 usage by a hybrid vesicular stomatitis virus/measles virus.

Measles virus (MV) immunosuppression is due to infection of SLAM-positive immune cells, whereas respiratory shedding and virus transmission are due to infection of nectin4-positive airway epithelial cells. The vaccine lineage MV strain Edmonston (MV-Edm) acquired an additional tropism for CD46 which is the basis of its oncolytic specificity. VSVFH is a vesicular stomatitis virus (VSV) encoding the MV-Edm F and H entry proteins in place of G.