Publications by authors named "Samuel O Lord"

Article Synopsis
  • Skeletal muscle is a versatile tissue influenced by various factors, playing a significant role in health, but the molecular mechanisms behind its functions remain complex and challenging to understand.
  • Protein ubiquitylation is a key post-translational modification that affects many biological processes, and while mass spectrometry techniques like ubiquitylomics help analyze this process, there are still limitations in studying its effects in skeletal muscle.
  • Utilizing ubiquitylomics can enhance our knowledge of protein ubiquitylation in muscle physiology, potentially leading to new therapeutic strategies for muscle-related issues.
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MuRF1 (Muscle-specific RING finger protein 1; gene name TRIM63) is a ubiquitin E3 ligase, associated with the progression of muscle atrophy. As a RING (Really Interesting New Gene) type E3 ligase, its unique activity of ubiquitylation is driven by a specific interaction with a UBE2 (ubiquitin conjugating enzyme). Our understanding of MuRF1 function remains unclear as candidate UBE2s have not been fully elucidated.

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Ingested galactose can enhance postexercise liver glycogen repletion when combined with glucose but effects on muscle glycogen synthesis are unknown. In this double-blind randomized study participants [7 men and 2 women; V̇o: 51.1 (8.

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Physical activity or regular exercise provides many beneficial effects towards human health, helping prevent and ameliorate metabolic diseases. However, certain molecular mechanisms that mediate these health benefits remain poorly understood. Parker et al.

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Mitophagy is a key process regulating mitochondrial quality control. Several mechanisms have been proposed to regulate mitophagy, but these have mostly been studied using stably expressed non-native proteins in immortalized cell lines. In skeletal muscle, mitophagy and its molecular mechanisms require more thorough investigation.

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