Publications by authors named "Samuel Metcalfe"
Article Synopsis
- - Glioblastoma (GBM) is the most aggressive brain cancer, largely driven by glioblastoma stem cells (GSCs) which contribute to its recurrence and make treatment difficult.
- - Natural killer (NK) cells have potential against GSCs but struggle with effectiveness in the GBM environment due to limited infiltration.
- - This study presents new image-based assays to evaluate NK cell movement and ability to kill GSCs, aiming to enhance NK cell immunotherapy for better GBM management.
Glioblastoma (GBM) poses a significant challenge in oncology and stands as the most aggressive form of brain cancer. A primary contributor to its relentless nature is the stem-like cancer cells, called glioblastoma stem cells (GSCs). GSCs have the capacity for self-renewal and tumorigenesis, leading to frequent GBM recurrences and complicating treatment modalities.
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