Establishing standardized immune phenotyping of metastatic melanoma by digital pathology.

CD8+ tumor-infiltrating T cells can be regarded as one of the most relevant predictive biomarkers in immune-oncology. Highly infiltrated tumors, referred to as inflamed (clinically "hot"), show the most favorable response to immune checkpoint inhibitors in contrast to tumors with a scarce immune infiltrate called immune desert or excluded (clinically "cold"). Nevertheless, quantitative and reproducible methods examining their prevalence within tumors are lacking.

[Future Medicine: Digital Pathology].

Future Medicine: Digital Pathology Pathology is facing a paradigm shift. Digitization enables highly efficient, networked diagnostics and the simplified exchange of expert knowledge. Algorithms for image analysis and artificial intelligence have the potential to further increase the quality of diagnostics in pathology.