Publications by authors named "Samuel M Rocha"
J Inorg Biochem
March 2023
Article Synopsis
- The study reports the creation and characterization of two new cobalt(II) coordination compounds, investigating their effects on Leishmania amazonensis, a parasite that causes leishmaniasis.
- Complex (1) showed no toxicity to mammalian cells and had moderate antiproliferative activity against the promastigote form of the parasite, while complex (2) was cytotoxic to mammalian cells but was also effective against the parasite.
- Mechanistic studies revealed that complex (1) induces mitochondrial dysfunction and apoptosis-like cell death in the parasites, with promising molecular docking results suggesting a potential interaction with crucial proteins, warranting further research.
