Light-induced photoreceptor degeneration may involve the NF kappa B/caspase-1 pathway in vivo.

Purpose: To determine the role of nuclear factor-kappaB (NFkappaB) in light-induced photoreceptor degeneration.

Methods: Dark-adapted BALB/cJ mice, 4-8 weeks, were exposed to an intense green light (3.1-3.

Increased nuclear factor-kappa B p65 immunoreactivity following retinal ischemia and reperfusion injury in mice.

Nuclear factor-kappaB (NF-kappaB) is a universal transcription factor and has previously been demonstrated to play an important role in CNS injury. This study investigated the expression of NF-kappaB in the inner layers of the retina in mice after retinal ischemia and reperfusion injury. Retinal ischemia was induced by elevation of intraocular pressure to 120 mmHg for 60 min.

NF-kappaB activation in light-induced retinal degeneration in a mouse model.

Purpose: To investigate the modulation of nuclear factor (NF)-kappaB in light-induced photoreceptor degeneration in a mouse model.

Methods: Mice were exposed to intense green light. Light-induced activation of NF-kappaB and its nuclear localization were studied by immunohistochemistry.