Intercellular communication in the innate immune system through the cGAS-STING pathway.

Type I interferons (IFNα/β) are pivotal to anti-viral defense. Although an absolute requirement for viral clearance, the presence of IFN in high doses sustained over time has been implicated to be the underlying cause of clinical outcomes such as interferonopathies. Therefore, tight regulation of cellular communication processes is required for tissue homeostasis.