Publications by authors named "Samuel Jacques"
Article Synopsis
- Riboswitches are RNA sequences that control gene expression by changing shape when specific metabolites bind to them.
- Recent studies using techniques like single-molecule FRET and SHAPE have investigated the folding pathway of an adenine riboswitch, revealing the existence of a crucial structural intermediate during the binding process.
- This intermediate state facilitates ligand recognition and helps shape the riboswitch's final structure, improving its ability to detect metabolites and regulate genes.
Systematic genetic interaction profiles can reveal the mechanisms-of-action of bioactive compounds. The imipridone ONC201, which is currently in cancer clinical trials, has been ascribed a variety of different targets. To investigate the genetic dependencies of imipridone action, we screened a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) knockout library in the presence of either ONC201 or its more potent analog ONC212.
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