Bolus-Tracked Biphasic Contrast-Enhanced CT Imaging Following Microwave Liver Ablation Improves Ablation Zone Conspicuity and Semi-automatic Segmentation Quality.

Purpose: Contrast-enhanced CT (CECT) may be performed immediately following microwave liver ablation for assessment of ablative margins. However, practices and protocols vary among institutions. Here, we compare a standardized bolus-tracked biphasic CECT protocol and compare this with a single venous phase fixed delay protocol for ablation zone (AZ) assessment.

Ultrasound-guided intra-tumoral administration of directly-injected therapies: a review of the technical and logistical considerations.

Background: Directly-injected therapies (DIT) include a broad range of agents within a developing research field in cancer immunotherapy, with encouraging clinical trial results in various tumour subtypes. Currently, the majority of such therapies are only available within clinical trials; however, more recently, talimogene laherparepvec (T-VEC, Imlygic) has been approved as the first oncolytic virus therapy in the USA and Europe. Our institution contributes to multiple different trials exploring the efficacy of DIT, the majority of which are performed by oncologists in clinic.

Response Evaluation Criteria in Gastrointestinal and Abdominal Cancers: Which to Use and How to Measure.

As the management of gastrointestinal malignancy has evolved, tumor response assessment has expanded from size-based assessments to those that include tumor enhancement, in addition to functional data such as those derived from PET and diffusion-weighted imaging. Accurate interpretation of tumor response therefore requires knowledge of imaging modalities used in gastrointestinal malignancy, anticancer therapies, and tumor biology. Targeted therapies such as immunotherapy pose additional considerations due to unique imaging response patterns and drug toxicity; as a consequence, immunotherapy response criteria have been developed.

Developing and validating a simple urethra surrogate model to facilitate dosimetric analysis to predict genitourinary toxicity.

Purpose: The urethra is a critical structure in prostate radiotherapy planning; however, it is impossible to visualise on CT. We developed a surrogate urethra model (SUM) for CT-only planning workflow and tested its geometric and dosimetric performance against the MRI-delineated urethra (MDU).

Methods: The SUM was compared against 34 different MDUs (within the treatment PTV) in patients treated with 36.

Multicentre validation of CT grey-level co-occurrence matrix features for overall survival in primary oesophageal adenocarcinoma.

Background: Personalising management of primary oesophageal adenocarcinoma requires better risk stratification. Lack of independent validation of proposed imaging biomarkers has hampered clinical translation. We aimed to prospectively validate previously identified prognostic grey-level co-occurrence matrix (GLCM) CT features for 3-year overall survival.

Association of dynamic contrast-enhanced MRI and F-Fluorodeoxyglucose PET/CT parameters with neoadjuvant therapy response and survival in esophagogastric cancer.

Introduction: Better predictive markers are needed to deliver individualized care for patients with primary esophagogastric cancer. This exploratory study aimed to assess whether pre-treatment imaging parameters from dynamic contrast-enhanced MRI and F-fluorodeoxyglucose (F-FDG) PET/CT are associated with response to neoadjuvant therapy or outcome.

Materials And Methods: Following ethical approval and informed consent, prospective participants underwent dynamic contrast-enhanced MRI and F-FDG PET/CT prior to neoadjuvant chemotherapy/chemoradiotherapy ± surgery.

State-of-the-art imaging in oesophago-gastric cancer.

Radiological investigations are essential in the management of oesophageal and gastro-oesophageal junction cancers. The current multimodal combination of CT, 18F-fluorodeoxyglucose positron emission tomography combined with CT (PET/CT) and endoscopic ultrasound (EUS) has limitations, which hinders the prognostic and predictive information that can be used to guide optimum treatment decisions. Therefore, the development of improved imaging techniques is vital to improve patient management.

Bladder paragangliomas: a pictorial review.

Bladder paragangliomas (bPGL) are rare neuroendocrine tumors arising from the sympathetic paraganglia present in the bladder wall. Bladder PGLs are typically submucosal or intramural but when subserosal may not be readily visible at cystoscopy. The average size at presentation is 3.

Multiparametric Ultrasound of Nonpalpable Focal Testicular Lesions.

Indeterminate nonpalpable focal testicular lesions have emerged as a clinical problem with the increasing use of scrotal ultrasound, particularly in the context of infertility. Conventional morphological ultrasound and color Doppler have been unreliable at differentiating benign from malignant lesions. Multiparametric ultrasound (mpUS) comprises real-time elastography and contrast-enhanced ultrasound as adjunctive tools, and is ready for use in most state-of-the-art ultrasound systems.

Multimodality Assessment of Cystic Renal Masses.

Renal cysts are a common imaging finding, often incidental. Ultrasound, CT and MRI are the main modalities responsible for renal cyst detection and characterization. These modalities often play a complementary role in modern radiological practice, each of them with strengths and limitations.

Imaging Features of Succinate Dehydrogenase-deficient Pheochromocytoma-Paraganglioma Syndromes.

Pheochromocytoma (PC) and paraganglioma (PGL) are rare neuroendocrine tumors that occur throughout the body from the base of the skull to the pelvis. Sympathetic catecholamine-secreting tumors may be associated with hyperadrenergic symptoms and long-term morbidity if they are untreated. Typically biochemically silent, head and neck PGLs may result in cranial nerve palsies and symptoms due to localized mass effect.

Automated Triaging of Adult Chest Radiographs with Deep Artificial Neural Networks.

Purpose To develop and test an artificial intelligence (AI) system, based on deep convolutional neural networks (CNNs), for automated real-time triaging of adult chest radiographs on the basis of the urgency of imaging appearances. Materials and Methods An AI system was developed by using 470 388 fully anonymized institutional adult chest radiographs acquired from 2007 to 2017. The free-text radiology reports were preprocessed by using an in-house natural language processing (NLP) system modeling radiologic language.

Lesser sac herniation: a rare cause of acute abdomen and bowel perforation.

Lesser sac herniation is a rare phenomenon, where the bowel protrudes through the epiploic foramen into the lesser sac. We describe the case of a 55-year-old male who presented with acute abdominal pain and in whose case the subtle findings of lesser sac herniation were missed during CT scan reporting. Re-review of the images after the patient's condition deteriorated found evidence of herniation, and re-scanning at that point demonstrated progression of the herniation, with bowel obstruction and perforation.