Publications by authors named "Samuel J Windross"
Article Synopsis
- Inflammatory bowel diseases (IBD) cause long-lasting inflammation in the digestive system, and scientists are looking into how stress inside cells (called ER stress) affects this.
- They found that when cells experience ER stress, the way they use certain nutrients changes, which might affect how severe IBD is and how well treatments work.
- The researchers discovered that not having enough of a nutrient called serine can mess up a signaling system that helps cells fight infections, but giving antioxidants can help improve this issue.
Article Synopsis
- Nucleic acids can trigger type I interferon (IFN-I) production and contribute to diseases like lupus by causing inflammation, primarily through the cGAS-STING pathway that requires STING trafficking from the ER to the Golgi for activation.
- Researchers studied the effects of a peptide called ISD017, which inhibits STING's downstream activities, including IFN-I production and inflammatory responses, using cell cultures, lupus mouse models, and lupus patient samples.
- ISD017 was found to block STING's trafficking and activity, reducing disease symptoms in mice and pathological cytokine responses in lupus patients, suggesting its potential as a therapeutic option for lupus.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFSTING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occurs. Although STING ER exit is the rate-limiting step in STING signaling, the mechanism that drives this process is not understood.
View Article and Find Full Text PDFType I interferons (IFNα/β) are pivotal to anti-viral defense. Although an absolute requirement for viral clearance, the presence of IFN in high doses sustained over time has been implicated to be the underlying cause of clinical outcomes such as interferonopathies. Therefore, tight regulation of cellular communication processes is required for tissue homeostasis.
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