Publications by authors named "Samuel Harry Myers"
Article Synopsis
- Synthetic lethality is emerging as a key strategy for anticancer therapies, expanding beyond just PARP inhibitors for BRCA1/2-defective tumors.
- New molecular targets, particularly in DNA damage response, are quickly progressing to clinical trials, showcasing the growing interest in synthetic lethal approaches.
- The article highlights the latest developments in synthetic lethal targets, discusses their design and therapeutic strategies, and ends with an exploration of the challenges and opportunities for future research in this area.
Questioning PCOS phenotypes for reclassification and tailored therapy.
Trends Endocrinol Metab
November 2023
Precise diagnoses are essential for defining appropriate treatments. This is particularly true for polycystic ovary syndrome (PCOS), whose phenotypical manifestations have recently suggested a possible diversity of etiological factors. PCOS is defined on the basis of gynecological and endocrinological alterations, but the patients often display considerable metabolic impairments, such as insulin resistance, that may worsen typical symptoms.
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