Publications by authors named "Samuel H Lai"

Background: The use of a watch and wait management strategy following a complete clinical response to neoadjuvant therapy for rectal cancer is increasing. However, insights into implementation, treatments, and outcomes, on a United States national level, are limited.

Objective: To investigate and report on watch & wait management practices and outcomes in the US.

View Article and Find Full Text PDF

Objective: Use of traditional scoring metrics for residency recruitment creates racial and gender bias. In addition, widespread use of pass/fail grading has led to noncomparable data. To adjust to these challenges, we developed a holistic review (HR) rubric for scoring residency applicants for interview selection.

View Article and Find Full Text PDF

Background: Total neoadjuvant therapy for locally advanced rectal cancer may include induction chemotherapy and chemoradiation or short-course radiotherapy and consolidative chemotherapy.

Methods: Patients with clinical stage 2 or 3 rectal cancer who received induction chemotherapy followed by long-course chemoradiation at the University of Colorado (2016-2020) or short-course radiotherapy followed by consolidative chemotherapy at Washington University (2017-2020) were assessed.

Results: Eighty-four patients received induction chemotherapy and chemoradiation and 83 received short-course radiotherapy and consolidative chemotherapy.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the effects of adjuvant chemotherapy on survival rates in rectal cancer patients who have achieved a pathologic complete response after neoadjuvant chemoradiotherapy and total mesorectal excision.
  • It included data from over 20,000 patients, focusing on those who received or did not receive adjuvant therapy, with findings indicating a significant survival advantage for those who underwent the additional treatment.
  • Results showed that patients who received adjuvant chemotherapy had a 5, 10, and 14-year survival rate of 93%, 85%, and 83%, respectively, compared to 87%, 67%, and 51% for those who did not receive it, suggesting a critical benefit
View Article and Find Full Text PDF

Background: Total neoadjuvant therapy in rectal cancer may increase pathological complete response rates, potentially allowing for a nonoperative approach.

Objective: The objective of this study was to identify patient and tumor characteristics that predict a complete response following total neoadjuvant therapy.

Design: This was a retrospective cohort study.

View Article and Find Full Text PDF

An 88-year-old man with no significant medical history, and in a good state of health, presented to the emergency department with 4 days of obstipation, progressive abdominal pain, and bloating. Examination revealed abdominal distension and generalized tenderness without signs of peritonitis. Laboratory values, including lactate and complete blood count, were within normal limits.

View Article and Find Full Text PDF

Objective: To evaluate the safety and effectiveness of infrainguinal artery revascularization via atherectomy supplemented with other endovascular techniques in an office endovascular center (OEC) setting.

Methods: A retrospective study was conducted examining 352 lower extremity atherectomy revascularization procedures between 2011 and 2016 at an OEC by five board-certified vascular surgeons. Patients received laser atherectomy or orbital atherectomy followed by angioplasty or angioplasty and stent placement as needed.

View Article and Find Full Text PDF

Objective: The objective of this study was to evaluate the safety and efficacy of a retrograde tibial approach in revascularization of lower extremities for treatment of ischemia in anatomically challenging patients.

Methods: This is a retrospective study of 57 procedures performed between 2012 and 2016 using the retrograde approach to treat patients with flush occlusion, inability to cross the lesion, failed bypass, or hostile groin. Demographic data, Rutherford classes, vessels treated, and approach were noted.

View Article and Find Full Text PDF