Publications by authors named "Samuel Ghatan"
We aimed to: (1) examine the relationship between glycemic control, BMD estimated from heel ultrasound (eBMD) and fracture risk in individuals with type 1 (T1D) and type 2 diabetes (T2D) and (2) perform a one-sample Mendelian randomization (MR) study to explore potential causal associations between glycemic control, eBMD, and fractures. This study comprised 452 131 individuals from the UK Biobank with glycated hemoglobin A1C (HbA) and eBMD levels. At baseline, 4078 participants were diagnosed with T1D and 23 682 with T2D.
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- * Sarcopenia (muscle loss) and osteoporosis (bone loss) are closely linked, with each condition serving as a predictor for the other, indicating the need for integrated research approaches.
- * A recent workshop emphasized the importance of muscle characterization in musculoskeletal studies, advocating for more recognition and research on muscle phenotyping in both human and animal models like zebrafish and mice.
Background: Type 2 diabetes (T2D) is a heterogeneous and polygenic disease. Previous studies have leveraged the highly polygenic and pleiotropic nature of T2D variants to partition the heterogeneity of T2D, in order to stratify patient risk and gain mechanistic insight. We expanded on these approaches by performing colocalization across GWAS traits while assessing the causality and directionality of genetic associations.
View Article and Find Full Text PDFClinical studies indicate that microvascular disease (MVD) affects bone microstructure and decreases bone strength in type 2 diabetes mellitus (T2D). Osteocytes are housed in small voids within the bone matrix and lacunae and act as sensors of mechanical forces in bone. These cells regulate osteoclastic bone resorption and osteoblastic bone formation as well as osteocytic perilacunar remodeling.
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- The study investigates whether baseline bone mineral density (BMD) or the rate of bone loss before the baseline is a better predictor of developing dementia and Alzheimer's disease (AD).
- A meta-analysis involved data from three longitudinal studies with over 4,400 participants aged 60 and above, focusing on BMD measurements and their correlation with dementia diagnoses within a 10-year follow-up.
- Results indicated that higher baseline BMD is significantly linked to a lower risk of dementia, while prior bone loss only showed a significant relationship in one of the studies included.
Background And Objectives: Low bone mineral density (BMD) and dementia commonly co-occur in older individuals, with bone loss accelerating in patients with dementia due to physical inactivity and poor nutrition. However, uncertainty persists over the extent to which bone loss already exists before onset of dementia. Therefore, we investigated how dementia risk was affected by BMD at various skeletal regions in community-dwelling older adults.
View Article and Find Full Text PDFPurpose Of Review: The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus.
Recent Findings: Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is associated with increased non-vertebral fracture risk and mortality.