Publications by authors named "Samuel Francisco"
Article Synopsis
- - Cyst-forming Apicomplexa (CFA) from the Sarcocystidae family are widespread pathogens affecting humans and livestock, primarily transmitted through the food chain and capable of forming long-lasting infectious tissue cysts in host animals.
- - Each species within this family has developed unique methods to efficiently transmit and maintain reservoirs globally, ensuring their lifecycle continues between intermediate and definitive hosts.
- - The study highlights the mRNA expression analysis of Besnoitia besnoiti, revealing its genome's similarity to other CFA and its potential as a model for understanding the biology and evolution of coccidian tissue cysts.
Monopolar spindle One Binder1 (MOB1) proteins are conserved components of the tumor-suppressing Hippo pathway, regulating cellular processes such as cytokinesis. Apicomplexan parasites present a life cycle that relies on the parasites' ability to differentiate between stages and regulate their proliferation; thus, Hippo signaling pathways could play an important role in the regulation of the apicomplexan life cycle. Here, we report the identification of one MOB1 protein in the apicomplexan .
View Article and Find Full Text PDFEndochin-like quinolones (ELQs) potently inhibit the proliferation of , and by targeting the cytochrome Qo and Qi sites and interfering with oxidative phosphorylation and pyrimidine biosynthesis. The activities of 14 different ELQs were assessed against tachyzoites grown in human foreskin fibroblasts (HFF) by quantitative real time PCR. The values for 50% proliferation inhibition (IC50) of five ELQs were determined in a 3-days growth assay after an initial screen of 12 ELQs at 0.
View Article and Find Full Text PDF