Association between circulating PCSK9 and proteinuria in nephrotic syndrome: A cross-sectional study.

Background: Nephrotic syndrome (NS) is associated with both hypercholesterolemia and hypertriglyceridemia, which could exacerbate disease progression and accelerate atherosclerosis. It has been reported that PCSK9, a proprotein convertase involved in hypercholesterolemia, was increased in patients with NS.

Objective: To investigate the association between PCSK9 concentrations and the magnitude of proteinuria.