Publications by authors named "Samuel D Maldonado"
Article Synopsis
- Plasmacytoid dendritic cells (pDCs) play a role in antifungal immunity, specifically interacting with the fungus Aspergillus fumigatus, but their exact mechanisms are still not completely understood.
- The study reveals that pDCs do not engulf Aspergillus spores but instead bind to the hyphal structures and become activated, increasing markers associated with immune response.
- Activation of pDCs is significantly enhanced by the C-type lectin receptor dectin-1, especially when stimulated indirectly through cytokines produced by other immune cells, suggesting that pDCs help amplify the immune response against fungal infections.
Background: Safety concerns for fluoroquinolones exist from animal studies demonstrating cartilage injury in weight-bearing joints, dependent on dose and duration of therapy. For children treated with levofloxacin or comparator in randomized, prospective, comparative studies for acute otitis media and community-acquired pneumonia, this 5-year follow-up safety study was designed to assess the presence/absence of cartilage injury.
Methods: Children enrolled in treatment studies were also enrolled in a 1-year follow-up safety study, which; focused on musculoskeletal adverse events (MSAE).
This investigation was designed to evaluate the single-dose pharmacokinetics of itraconazole, hydroxyitraconazole, and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) after intravenous administration to children at risk for fungal infection. Thirty-three children aged 7 months to 17 years received a single dose of itraconazole (2.5 mg/kg in 0.
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