Publications by authors named "Samuel D Cutler"
Article Synopsis
- Multiple myeloma is classified into two main types based on genomic alterations: hyperdiploidy and IgH translocations, assessed at diagnosis using FISH for risk stratification.
- This study sequenced 26 genes in 76 multiple myeloma patients and found 255 mutations and 33 focal copy number variations, linking high-severity mutations to poorer patient outcomes.
- Mutations identified were different from traditional FISH risk markers, allowing better risk classification, with some patients showing severe forms like plasma cell leukemia despite being initially classified as standard risk.
Multiple myeloma (MM) is an incurable hematological malignancy that relies on cytogenetic determination of copy number abnormalities (CNAs) for prognosis and management. Low-depth whole genome sequencing (LD-WGS) is a cost-effective alternative to targeted genomics for CNA detection, but its value has yet to be explored in MM. DNA from CD138+ cells from MM patients were sequenced using an Illumina NextSeq at <1x depth (ultralow-depth).
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