Publications by authors named "Samuel Christopher Katru"
Identification and characterization of a novel nematode pan allergen (NPA) from Wuchereria bancrofti and their potential role in human filarial tropical pulmonary eosinophilia (TPE).
Samuel Christopher Katru Anand Setty Balakrishnan Gnanasekar Munirathinam Azadeh Hadadianpour Scott A Smith
PLoS Negl Trop Dis
February 2024
Article Synopsis
- Tropical pulmonary eosinophilia (TPE) is a respiratory syndrome linked to lymphatic filariasis (LF), caused by a parasitic infection transmitted by mosquitoes, with microfilariae playing a key role in TPE.
- Researchers screened a cDNA library of Wuchereria bancrofti microfilariae and identified a new molecule, named Nematode Pan Allergen (NPA), that resembles known allergens and can trigger immune responses like histamine release and inflammation.
- The study concludes that the NPA protein from microfilariae may significantly contribute to TPE pathology, suggesting that targeting NPA could help mitigate symptoms in individuals infected with LF.