Publications by authors named "Samuel B Yoshua"
Nucleic Acids Res
September 2021
Article Synopsis
- Nucleoid-associated proteins (NAPs), like Integration Host Factor (IHF), play a key role in organizing prokaryotic DNA and regulating gene activity.
- IHF significantly bends DNA at specific sequences relevant to transcription and recombination while also compacting DNA non-specifically.
- Recent studies reveal that IHF binds DNA in three distinct modes—'associated', 'half-wrapped', and 'fully-wrapped'—with only the 'fully-wrapped' mode being sequence-specific, suggesting a complex mechanism for how NAPs facilitate DNA organization.
