Publications by authors named "Samuel B Van Gordon"

Purpose: Interstitial cystitis/bladder pain syndrome is a bladder pain disorder associated with voiding symptomatology and other systemic chronic pain disorders. Currently diagnosing interstitial cystitis/bladder pain syndrome is complicated as patients present with a wide range of symptoms, physical examination findings and clinical test responses. One hypothesis is that interstitial cystitis symptoms arise from increased bladder permeability to urine solutes.

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Article Synopsis
  • Researchers studied cats with feline interstitial cystitis to identify protein expression abnormalities in their urothelium and compared it to human interstitial cystitis cases.
  • Analysis involved examining biopsies from 8 affected cats and 7 healthy controls using immunohistochemistry, revealing significant differences in protein expression patterns.
  • The findings indicated that a majority of feline cystitis samples showed abnormal protein expression, indicating similarities between feline and human interstitial cystitis mechanisms, thus supporting the cat model for future research.
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Article Synopsis
  • Interstitial cystitis/painful bladder syndrome is a debilitating condition diagnosed primarily through symptoms like pain and urgency, without a definitive diagnostic test currently available.* -
  • In a rat study, researchers used contrast-enhanced magnetic resonance imaging (MRI) with a special contrast agent to visualize bladder and colon effects after inducing interstitial cystitis with protamine sulfate.* -
  • The results showed significant changes in bladder permeability and colon uptake of the contrast agent, suggesting this MRI technique could be a promising diagnostic tool for interstitial cystitis and help understand the interactions between different organs.*
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As the field of tissue engineering develops, researchers are faced with a large number of degrees of freedom regarding the choice of material, architecture, seeding, and culturing. To evaluate the effectiveness of a tissue-engineered strategy, histology is typically done by physically slicing and staining a construct (crude, time-consuming, and unreliable). However, due to recent advances in high-resolution biomedical imaging, microcomputed tomography (μCT) has arisen as a quick and effective way to evaluate samples, while preserving their structure in the original state.

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