Publications by authors named "Samuel Angel"

Article Synopsis
  • The study highlights the urgent need for improved treatments for chronic myeloid leukemia (CML), given the high incidence and mortality rates among men and women.
  • It investigates the potential enhanced effects of combining inecalcitol with existing therapies imatinib and dasatinib on various cancer cell lines.
  • Results showed that while some cell lines were resistant, AR-230 and LAMA-84-s exhibited significant cell-killing effects, suggesting that the effectiveness of combined treatments varies depending on the specific cell type.
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Purpose: Septoplasty and rhinoplasty are common otolaryngological procedures, often combined as septorhinoplasty (SRP), offering aesthetic and functional benefits. These surgeries are believed to potentially risk postoperative infections due to natural bacterial flora in the nares. This study evaluates the effectiveness of prophylactic antibiotics in reducing post-surgical infection complications.

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We report stable and heterogeneous graphene oxide (GO)-intercalated copper as an efficient catalyst for the organic transformations in green solvents. The GO-intercalated copper(II) complex of bis(1,4,7,10-tetraazacyclododecane) [Cu(II)-bis-cyclen] was prepared by a facile synthetic approach with a high dilution technique. The as-prepared GO-Cu(II)-bis-cyclen nanocomposite was used as a click catalyst for the 1,3 dipolar Huisgen cycloaddition reaction of terminal alkyne and azide substrates.

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Article Synopsis
  • Surgical site infections (SSIs) present significant challenges for patients and healthcare providers, largely due to sutures that can harbor bacteria and contribute to these infections.
  • Traditional antibiotic-coated sutures are becoming less effective due to rising antibiotic resistance; however, metallic nanoparticles (MNPs) show promise in tackling this issue by effectively killing bacteria without triggering resistance.
  • The study developed a new method to coat sutures with MNPs, leading to strong antibacterial effects and maintaining the sutures' strength and safety for cells, marking a potential advancement in SSI prevention.
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With more than 50% of bacteria resistant to standard antibiotics, new strategies to treat bacterial infection and colonization are needed. Based on the concept of targeting the bacteria synergistically on various fronts, it is hypothesized that an electrical insult associated with antibacterial materials may be a highly effective means of killing bacteria. In this work, an injectable conductive gel based on silk fibroin (SF) and silver nanoparticles (Ag-NPs) is synthesized, capable of coating a zone of injury, allowing the application of a low electrical current to decrease bacterial contamination.

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The study was undertaken to determine histological distortions occurring in the pea testa (skin) as a result of various force applications. Multi-directional compression caused bending of macrosclereids and flattening of osteosclereids. Unidirectional pressure caused similar deformations plus eventual separation between cells; shearing caused bending, buckling and wedging of macrosclereids; bruising resulted in cracks between macrosclereids and buckling.

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