Publications by authors named "Samuel A Maiwald"
Article Synopsis
- This study focuses on how E3 ligases interact with substrates through specific C-degron sequences, which are essential for the ubiquitin-proteasome system’s function in protein degradation.*
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- Researchers compared ubiquitylation activities of various substrates and used techniques like biochemistry and crystallography to uncover how different E3 ligases from the KLHDCX family recognize C-degrons.*
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- Findings indicate that while a common anchoring motif aids in binding, variations in structure and additional interactions influence which substrates can be recognized and degraded, highlighting the complexity of substrate specificity.*
