Degrees of dysplasia based on viral typing in patients with cidofovir use and recurrent respiratory papillomatosis.

Objectives/hypothesis: To evaluate the degree of dysplasia following cidofovir injections while documenting human papillomavirus (HPV) type in patients with recurrent respiratory papillomatosis (RRP).

Study Design: Retrospective chart review.

Methods: Demographic data, operative reports, and pathology results were reviewed from 25 patients with RRP who had had cidofovir injections.

A regulated delivery system for inner ear drug application.

Objective: We have recently developed a novel inner ear drug delivery system using chitosan glycerophosphate (CGP) hydrogel loaded with drugs commonly used for treatment of inner ear diseases, significantly improving the drugs' sustained delivery. The goal of this study is to evaluate the effectiveness of chitosanase as a "switch off" mechanism for this drug delivery system when side effects and potential ototoxicities appear during treatment. To evaluate this effect, we tested gentamicin (GENT) in the inner ear following CGP delivery with/without regulation.