Using predictive models to identify kelp refuges in marine protected areas for management prioritization.

Kelp forests serve as the foundation for shallow marine ecosystems in many temperate areas of the world but are under threat from various stressors, including climate change. To better manage these ecosystems now and into the future, understanding the impacts of climate change and identifying potential refuges will help to prioritize management actions. In this study, we use a long-term dataset of observations of kelp percentage cover for two dominant canopy-forming species off the coast of Victoria, Australia: Ecklonia radiata and Phyllospora comosa.

Embodied emotions in ancient Neo-Assyrian texts revealed by bodily mapping of emotional semantics.

Emotions are associated with subjective emotion-specific bodily sensations. Here, we utilized this relationship and computational linguistic methods to map a representation of emotions in ancient texts. We analyzed Neo-Assyrian texts from 934-612 BCE to discern consistent relationships between linguistic expressions related to both emotions and bodily sensations.

Negative regulation of activation-induced cytidine deaminase gene transcription in developing B cells by a PU.1-interacting intronic region.

Activation-induced cytidine deaminase (AID, encoded by Aicda) plays a key role in somatic hypermutation and class switch recombination in germinal center B cells. However, off-target effects of AID are implicated in human leukemia and lymphoma. A mouse model of precursor B cell acute lymphoblastic leukemia driven by deletion of the related transcription factors PU.

Six types of loves differentially recruit reward and social cognition brain areas.

Feelings of love are among the most significant human phenomena. Love informs the formation and maintenance of pair bonds, parent-offspring attachments, and influences relationships with others and even nature. However, little is known about the neural mechanisms of love beyond romantic and maternal types.

Sisterhood predicts similar neural processing of a film.

Relationships between humans are essential for how we see the world. Using fMRI, we explored the neural basis of homophily, a sociological concept that describes the tendency to bond with similar others. Our comparison of brain activity between sisters, friends and acquaintances while they watched a movie, indicate that sisters' brain activity is more similar than that of friends and friends' activity is more similar than that of acquaintances.

Innovative numerical modeling for predicting soil relaxation in the design of twin circular culverts.

This study presents a finite difference model for analyzing ground stability and settlement of twin circular culverts in undrained clay. The model is verified through simulations of soil movement and relaxation around a tunnel-boring machine's shield. Stability numbers and ground settlement are evaluated across various culvert geometries and soil ratios and compared to rigorous solutions and previous models.

N-Acetylcysteine Alters Disease Progression and Increases Janus Kinase Mutation Frequency in a Mouse Model of Precursor B-Cell Acute Lymphoblastic Leukemia.

B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent type of cancer in young children and is associated with high levels of reactive oxygen species (ROS). The antioxidant N-acetylcysteine (NAC) was tested for its ability to alter disease progression in a mouse model of B-ALL. Mb1-CreΔPB mice have deletions in genes encoding PU.

Bodily maps of musical sensations across cultures.

Emotions, bodily sensations and movement are integral parts of musical experiences. Yet, it remains unknown i) whether emotional connotations and structural features of music elicit discrete bodily sensations and ii) whether these sensations are culturally consistent. We addressed these questions in a cross-cultural study with Western (European and North American, n = 903) and East Asian (Chinese, n = 1035).

IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression.

Precursor B cell acute lymphoblastic leukemia (Pre-B-ALL) arises from developing B cells and frequently involves mutations in genes encoding transcription factors. In this study, we investigated the function of mutations in the transcription factor IKZF3 (Aiolos), R137* and H195Y, discovered in a mouse model of pre-B-ALL. R137* IKZF3 mutation resulted in a truncated protein, while electrophoretic mobility shift assay showed that H195Y IKZF3 mutation resulted in a protein with altered DNA binding.

Hippocampus-Centered Network Is Associated With Positive Symptom Alleviation in Patients With First-Episode Psychosis.

Background: Previous functional magnetic resonance imaging studies have reported widespread brain functional connectivity alterations in patients with psychosis. These studies have mostly used either resting-state or simple-task paradigms, thereby compromising experimental control or ecological validity, respectively. Additionally, in a conventional functional magnetic resonance imaging intrasubject functional connectivity analysis, it is difficult to identify which connections relate to extrinsic (stimulus-induced) and which connections relate to intrinsic (non-stimulus-related) neural processes.

Ideological values are parametrically associated with empathy neural response to vicarious suffering.

Several studies in political psychology reported higher levels of empathy among political leftists (i.e. liberals) as compared to political rightists (i.

Decoding brain basis of laughter and crying in natural scenes.

Laughter and crying are universal signals of prosociality and distress, respectively. Here we investigated the functional brain basis of perceiving laughter and crying using naturalistic functional magnetic resonance imaging (fMRI) approach. We measured haemodynamic brain activity evoked by laughter and crying in three experiments with 100 subjects in each.

Lipreading a naturalistic narrative in a female population: Neural characteristics shared with listening and reading.

Introduction: Few of us are skilled lipreaders while most struggle with the task. Neural substrates that enable comprehension of connected natural speech via lipreading are not yet well understood.

Methods: We used a data-driven approach to identify brain areas underlying the lipreading of an 8-min narrative with participants whose lipreading skills varied extensively (range 6-100%, mean = 50.

Racial differences in treatment among patients with acute headache evaluated in the emergency department and discharged home.

Background: Prior research has demonstrated the widespread presence of racial disparities in emergency department (ED) care and analgesia. We hypothesized that racial disparities continue to exist in ED analgesic prescribing patterns, time to analgesia, and time to provider in the treatment of headache.

Methods: We performed a retrospective cohort study of patients presenting to a large tertiary academic ED with chief complaint of headache.

Exploring the Interpersonal Level of Music Performance Anxiety: Online Listener's Accuracy in Detecting Performer Anxiety.

Music performance anxiety (MPA) affects musicians at various stages of a performance, from its preparation until the aftermath of its delivery. Given the commonality and potentially grave consequences of MPA, it is understandable that much attention has been paid to the musician experiencing it. Consequently, we have learned a great deal about the intrapersonal level of MPA: how to measure it, treatments, experimental manipulations, and subjective experiences.

Processing of an Audiobook in the Human Brain Is Shaped by Cultural Family Background.

Perception of the same narrative can vary between individuals depending on a listener's previous experiences. We studied whether and how cultural family background may shape the processing of an audiobook in the human brain. During functional magnetic resonance imaging (fMRI), 48 healthy volunteers from two different cultural family backgrounds listened to an audiobook depicting the intercultural social life of young adults with the respective cultural backgrounds.

Classification of emotion categories based on functional connectivity patterns of the human brain.

Neurophysiological and psychological models posit that emotions depend on connections across wide-spread corticolimbic circuits. While previous studies using pattern recognition on neuroimaging data have shown differences between various discrete emotions in brain activity patterns, less is known about the differences in functional connectivity. Thus, we employed multivariate pattern analysis on functional magnetic resonance imaging data (i) to develop a pipeline for applying pattern recognition in functional connectivity data, and (ii) to test whether connectivity patterns differ across emotion categories.

Rhythmic Neural Patterns During Empathy to Vicarious Pain: Beyond the Affective-Cognitive Empathy Dichotomy.

Empathy is often split into an affective facet for embodied simulation or sometimes sensorial processing, and a cognitive facet for mentalizing and perspective-taking. However, a recent neurophenomenological framework proposes a graded view on empathy (i.e.

Movies and narratives as naturalistic stimuli in neuroimaging.

Using movies and narratives as naturalistic stimuli in human neuroimaging studies has yielded significant advances in understanding of cognitive and emotional functions. The relevant literature was reviewed, with emphasis on how the use of naturalistic stimuli has helped advance scientific understanding of human memory, attention, language, emotions, and social cognition in ways that would have been difficult otherwise. These advances include discovering a cortical hierarchy of temporal receptive windows, which supports processing of dynamic information that accumulates over several time scales, such as immediate reactions vs.

Using the Session Rating of Perceived Exertion to Quantify Training Load in a Men's College Soccer Team.

Sams, ML, Wagle, JP, Sato, K, DeWeese, BH, Sayers, AL, and Stone, MH. Using the session rating of perceived exertion to quantify training load in a men's college soccer team. J Strength Cond Res 34(10): 2793-2799, 2020-The purpose of this study was to examine the training load (TL) programming of 3 training groups of a National Collegiate Athletic Association Division I men's college soccer team across a season.

Inter-subject Similarity of Brain Activity in Expert Musicians After Multimodal Learning: A Behavioral and Neuroimaging Study on Learning to Play a Piano Sonata.

Human behavior is inherently multimodal and relies on sensorimotor integration. This is evident when pianists exhibit activity in motor and premotor cortices, as part of a dorsal pathway, while listening to a familiar piece of music, or when naïve participants learn to play simple patterns on the piano. Here we investigated the interaction between multimodal learning and dorsal-stream activity over the course of four weeks in ten skilled pianists by adopting a naturalistic data-driven analysis approach.

Auditory representation of learned sound sequences in motor regions of the macaque brain.

Human speech production requires the ability to couple motor actions with their auditory consequences. Nonhuman primates might not have speech because they lack this ability. To address this question, we trained macaques to perform an auditory-motor task producing sound sequences via hand presses on a newly designed device ("monkey piano").

Social perspective-taking shapes brain hemodynamic activity and eye movements during movie viewing.

Putting oneself into the shoes of others is an important aspect of social cognition. We measured brain hemodynamic activity and eye-gaze patterns while participants were viewing a shortened version of the movie 'My Sister's Keeper' from two perspectives: that of a potential organ donor, who violates moral norms by refusing to donate her kidney, and that of a potential organ recipient, who suffers in pain. Inter-subject correlation (ISC) of brain activity was significantly higher during the potential organ donor's perspective in dorsolateral and inferior prefrontal, lateral and inferior occipital, and inferior-anterior temporal areas.