This review basically concerned with the application of different Schiff bases (SB) based fluorimetric (turn-off and turn-on) and colorimetric chemosensors for the detection of heavy metal cations particularly Al(III), Fe(III), and Cr(III) ions. Chemosensors based on Schiff bases have exhibited outstanding performance in the detection of different metal cations due to their facile and in-expensive synthesis, and their excellent coordination ability with almost all metal cations and stabilize them in different oxidation states. Moreover, Schiff bases have also been used as antifungal, anticancer, analgesic, anti-inflammatory, antibacterial, antiviral, antioxidant, and antimalarial etc.
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