Publications by authors named "Samridhi Johri"
Leishmaniasis is a complex of neglected tropical diseases caused by various species of leishmanial parasites that primarily affect the world's poorest people. A limited number of standard medications are available for this disease that has been used for several decades, these drugs have many drawbacks such as resistance, higher cost, and patient compliance, making it difficult to reach the poor. The search for novel chemical entities to treat leishmaniasis has led to target-based scaffold research.
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- Leishmaniasis is a neglected tropical disease affecting the poorest populations, caused by leishmanial parasites, and is difficult to treat due to limited medications and issues like drug resistance and cost.
- Research is focusing on developing new treatments using thiochromone compounds and studying their interaction with a specific target, N-myristoyl transferase (NMT), which is crucial for the parasite's growth in humans.
- The study employs advanced techniques like in-silico docking, toxicity prediction, and molecular dynamics simulations to evaluate the stability and binding patterns of the newly designed drugs.