[The effectiveness of polymethylsiloxane as a hemosorbent in experiments on obstructive jaundice].

It was established in experiment that the sorption properties of siliconorganic sorbent polymethylsiloxan (PMS) dominate significantly over the same of haemosorbent SKN-1K concerning common bilirubin level. It is possible to use PMS for haemosorption in obturating jaundice, viral hepatitis and in haemoperfusion as well.

[The interaction of pathogenic microorganisms with the sorbent polymethylsiloxane].

The method of electron microscopy has been used to study adhesion of the microbic cells of standard strains of Staphylococcus aureus, Escherichia coli and fungi of genus Candida on the organosilicon sorbent polymethylsiloxane (PMS) and medicamentous complex containing it. This complex contains furazolidone and metronidazole immobilized on silver ions-modified PMS. It is shown that the adhesion of microorganisms is accompanied by their destruction whose rate on pure PMS and medicamentous complex is different.

[Enterosorption in the treatment of chronic kidney failure in patients with surgical diseases of the kidneys].

Enterosgel was used in 89 patients with different stages of renal failure treated surgically and medically. It is concluded that isolated or complex detoxication using enterosgel is a perspective approach in the treatment of patients with surgical renal diseases complicated by chronic renal failure. The use of enterosorption in the preoperative period allows to perform operative intervention in situations when infusion treatment by traditional methods was not sufficient.

[The adhesion of pathogenic microflora on carbon sorbents].

The adsorbing activity of granulated carbonic sorbents SKN and KAU, as well as their oxidated forms, containing protogenic carboxylic and phenolic groups with respect to Shigella flexneri, Salmonella typhimurium, Escherichia coli, Streptococcus aureus and Pseudomonas aeruginosa pathogenic strains has been studied. As shown in this study, the process of interaction between microorganisms and carbonic sorbents has two stages. At the first stage the main role is played by long-distance electrostatic forces and at the second stage, by Van der Waals short-distance forces, as well as bonds formed between cell structures and surface groupings of carbonaceous materials.

[Enteral detoxication using polymethylsiloxane in the comprehensive treatment of septic forms of acute hematogenous osteomyelitis in newborn babies].

With regard for the role of bacterial and viral toxins and proteases in the pathogenesis of septic forms of acute hematogenous osteomyelitis, the use of enteral detoxication in the pediatric practice has been substantiated. The authors within 1988-1989, in 35 newborns with septic forms of acute hematogenous osteomyelitis used for detoxication the "Enterosgel" preparation. Control of the state of patients was accomplished by means of bacteriologic, biochemical and immunologic methods.

[Enterosorption in the combined treatment of patients with viral hepatitis].

The authors studied the efficacy of using USSR-made adsorbent "Enterosgel" in the complex treatment of viral hepatitis. A scheme of employment of the drug is described. Recommendations on the doses and duration of treatment are given.

[Preoperative enterosorption as a method for preventing postoperative complications in mechanical jaundice in cancer patients].

Enterosorption as component of preoperative preparation of patients with cancer-induced mechanical jaundice assured subsidence of intoxication, improvement in hepatic and renal functions, better postoperative course, lower rates of purulent and other postoperative complications and lower postoperative lethality.

[The use of polymethylsiloxane adsorbents in the treating early intoxication in patients following surgery of gastrointestinal hemorrhage].

A detoxicative effect of the use of polymethylsiloxane enterosorbents in the clinic is noted.

[The use of silicon organic sorbents for the local treatment of burn wounds].

The applicative-sorptive method of treatment was used by the authors in 57 patients ranging in age from 18 to 60 years with II-III AB degree burns of 10 to 50% of the body surface. The decrease in activity of proteolytic enzymes in the wound discharge, the increase in the activity of microbicidal systems of neutrophilic leukocytes, and formation of a phagocytic type of local resistance of an organism were noted. The epithelization of II-III A degree burn wounds accelerated, and the area of deep burn wounds reduced in patients.

[Study of general toxic properties and side effects of polymethylsiloxane and gentamicin immobilized on it].

A long-acting dosage form for local use of gentamicin immobilized on polymethylsiloxane, a silicon organic adsorbent was developed. It combined the antimicrobial spectrum of gentamicin and the local sorption-detoxication action of the matrix. In acute and chronic experiments on 5 species of laboratory animals it was shown that polymethylsiloxane had no general toxic action on the animals, no damaging action on their internal organs, did not affect their functions and the state of the biological fluids, had no pyrogenic or allergenic effect.