Hydrophilization and Functionalization of Fullerene C with Maleic Acid Copolymers by Forming a Non-Covalent Complex.

In this study, we report an easy approach for the production of aqueous dispersions of C fullerene with good stability. Maleic acid copolymers, poly(styrene--maleic acid) (SM), poly(N-vinyl-2-pyrrolidone--maleic acid) (VM) and poly(ethylene--maleic acid) (EM) were used to stabilize C fullerene molecules in an aqueous environment by forming non-covalent complexes. Polymer conjugates were prepared by mixing a solution of fullerene in N-methylpyrrolidone (NMP) with an aqueous solution of the copolymer, followed by exhaustive dialysis against water.

One-Pot Synthesis of Colloidal Hybrid Au (Ag)/ZnO Nanostructures with the Participation of Maleic Acid Copolymers.

One-pot synthesis of colloidal Au/ZnO and Ag/ZnO nanohybrid structures was carried out. The copolymers of maleic acid-poly(N-vinyl-2-pyrrolidone--maleic acid), poly(ethylene--maleic acid), or poly(styrene--maleic acid) were used as templates for the sorption of cations of metals-precursors and stabilization of the resulting nanoheterostructures. Simultaneous production of two types of nanoparticles has been implemented under mild conditions in an aqueous alkaline medium and without additional reagents.

Investigation of the Binding of Lectins with Polymer Glycoconjugates and the Glycoconjugates Containing Silver Nanoparticles by Means of Optical Spectroscopy and Light Scattering.

The synthesis of glycoconjugates, lectin-specific polymers containing a carbohydrate ligand (spacered residue of N-acetyl-D-glucosamine, β-N-Gly-GlcNAc) has been carried out. Glyconanoparticles (glycol-NPs) containing a label detectable by means of spectrophotometry, silver nanoparticles, have been prepared on the basis of the glycoconjugates. Copolymers of maleic anhydride with ethylene or -vinylpyrrolidone have been used as a carrier to introduce the carbohydrate ligand and a stabilizer of silver nanoparticles.

COVID-19, Acute Lymphoblastic Leukemia, and Down Syndrome: A Short Review and a Case Report.

SARS-CoV-2 which causes COVID-19 has been a great challenge to treat and deal with; despite strict measures that had been implemented by governments and organizations, worrying rates of morbidity and mortality are still being reported. Although available data have expressed that moderate or even mild forms of the disease are expected amongst most pediatrics cases, minimal data are available on the prognosis and the disease's complications on the immunocompromised, especially oncology patients. We report a case of relapsed precursor B-cell acute lymphoblastic leukemia of a child with Down syndrome and COVID-19 and outline the treatment regimen that we used.

Synthesis of magnetic chitin-adsorbent for specific proteins.

A simple, convenient and inexpensive method for the preparation of magnetic chitin composite, in which magnetite particles are densely covered with the polysaccharide shell has been developed. Two-step procedure for magnetic chitin preparation includes: (i) adsorption of chitosan onto magnetite particles and (ii) N-selective acetylation of chitosan to produce magnetic chitin. The composite combines the magnetic properties of magnetite and the adsorption properties of chitin.

[Possibilities for the instrumental monitoring of neuralgia therapy].

Aim: To study the possibility of using a paired (test) H-reflex recovery test in the expert assessment of the intensity of acute pain syndromes and in the control of performed therapy.

Subjects And Methods: The authors analyzed 40 patients treated for radicular pain syndrome (RPS) caused by disk protrusion or herniation at the lumbar spine with the pain intensity of up to 9 points on digital rank scale of pain. As a clinical model they used a pathogenetically sound therapeutic blockade method including glucocorticosteroids for the therapy of acute neuralgia and basic medical therapy with Arcoxia 120 mg/day.

[Some aspects of terminology, classification and incidence of hypodontia].

The paper presents the data of literature review on epidemiology, patterns and prevalence of hypodontia depending on race, nationality and gender of the patients. Correlation between congenital absence of the temporary and permanent teeth are discussed as well as the matters of the terminology and classification depending on the severity of this abnormality.

[Treatment and rehabilitation of patients with pain syndrome in surgical clinic].

Though the progress of modern medicine in understanding the mechanisms of pain and its treatment is significant, the problem of organizing help to the patients with pain syndrome is still actual and undecided. The issue highlights the general types of pain among surgical patients, as well as the integrative approach to the treatment and rehabilitation.

[The necessity and possibilities of the antipain help organization in multyprofile clinics].

The personal work experience of the department of pain syndrome and analysis of foreign algologic service clearly demonstrated the necessity of similar adequate hierarchical medical service for treatment of chronic pain. The following principles should build the backbone of the service: multidisciplinary approach, usage of both traditional and alternative medicine, availability of help and stable feedback with tertiary hospitals. The algologic service should perform diagnostic, advisory and expert functions.

Copolymers of maleic acid and their amphiphilic derivatives as stabilizers of silver nanoparticles.

Silver nanoparticles were prepared by reduction of the corresponding metal salt with NaBH(4) in the presence of appropriate dispersing agents, namely, copolymers of maleic acid: poly(N-vinyl-2-pyrrolidone-alt-maleic acid), poly(ethylene-alt-maleic acid), poly(styrene-alt-maleic acid) or their amphyphilic derivatives. A thorough study of the whole process of silver nanoparticles production including formation of polymeric silver salt and stabilization of nanoparticles has been carried out. The degree of cooperativity of copolymer silver ions binding process and binding capacity of copolymers with respect to silver ions was calculated.

[New liposomal forms of antifungal antibiotics, modified by amphiphilic polymers].

A method has been developed, for incorporating macrocyclic polyene antibiotics nistatin and amphotericin B into liposomes containing phosphatidylcholine and cholesterol (7:3) or phosphatidylcholine, cholesterol, and cardiolipin (7:3:1), the membranes of which were modified with an amphiphilic polymer of N-vinylpyrrolidone, carrying one terminal n-octadecyl group and having a molecular weight of 4000 Da. The amount of antibiotics within such liposomal nanocarriers may be as high as 17-22%. It was demonstrated that the modified liposomes have sizes in the range 150-200 nm and exhibit increased long-term storage stability and increased resistance to disrupting agents (Triton X-100 or ethanol) and ultrasound.

[Biospecific properties of lysine-contained polyelectrolyte coatings for devices contacting blood].

Biospecific properties of thromboresistant bilayer and multilayer coatings based on polyelectrolyte complexes of modified copolymer of N-vinylpyrrolidone and maleic acid (VPMA) with chitosan, amphiphilic chitosan or albumin were investigated. VPMA contained affinity ligand towards plasminogen--alpha-amino coupled lysine residues. Polyethylene and polystyrene surfaces were investigated before and after their covering by protective polyelectrolyte coatings.

Efficacy of neuroprotectors in patients with tension headaches.

Studies were performed on 126 patients with chronic tension headache (CTH). Patients were divided into two groups - an experimental group (64 patients) and a control group (62). Control patients received standard treatment (tizanidine, fluoxetine, vinpocetin, and manual acupressure of active points in the trapezius muscles and the temporomastoid area of the head); the experimental group also received Mexidol.

Polyelectrolyte thromboresistant affinity coatings for modification of devices contacting blood.

The modification of hydrophobic polyethylene/polystyrene surfaces of medical devices with bilayer/multilayer coatings (BCs/MCs) based on polyelectrolyte complexes (PEC) of modified poly(N-vinylpyrrolidone-co-maleic acid) copolymer (VPMA) with chitosan, amphiphilic chitosan, or albumin was studied. The VPMA contained l-Lysine as affinity ligand for plasminogen attached through alpha-amino group. The surface properties and chemical composition of the surfaces investigated were analyzed, using sessile-drop water contact angle measurements, attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM).

[Neureprotective drugs efficiency in patients with chronic tension headaches].

Authors examined 126 patients with chronic tension headaches. Patients were divided in two groups: general and control. The control group received conventional therapy (tizanidin, fluoxetin, vinpocetin, manual acupressure active points of m.

[Sorption of wheat seed lectin by polyelectrolyte complexes of chitosan].

The possible application of polyelectrolyte complexes (PEC) of chitosan and copolymers of maleic acid with N-vinylpyrrolidone, styrene, and ethylene and/or chitin cross-linked sorbents (CCLS) synthesized on the basis of PEC for sorption of wheat germ agglutinin (WGA) was studied. The synthesis of spherically granulated sorbents was shown. Compared to unmodified chitosan, there was a significant increase in sorption of WGA by the PEC: PEC, 2.

[Comparative study of dimephosphon and xidiphone efficacy in steroid-induced osteoporosis in rats].

The efficacy of dimephosphon in comparison with xydiphone was studied in rats with an osteoporosis model induced by prednisolone administration at a daily dose of 50 mg/kg over a period of 14 days. The prednisolone treatment led to an increase in the content of oxyproline (a marker of bone resorption), calcium, and inorganic phosphates in the urine. Dimephosphon (monophosphate) decreased the levels of oxyproline, calcium, and inorganic phosphate in the urine.

[An enterosorbent with trimethylaminoethanol chloride. 2. Hypolipidemic action and effect on cholesterol absorption in the intestine (experimental data)].

Enterosorbent containing trimethyl aminoethanol chloride administered per os into rabbits accelerated the rate of experimental hypercholesterolemia regression. Moreover, this substance decreased 4-14C-cholesterol absorption in the rat intestine.

[Enterosorbent with immobilized trimethylaminoethanol chloride. I. Hypolipidemic properties].

Hypolipidemic properties of the synthesized enterosorbent, water soluble polymer containing covalently immobilized trimethylamine ethanol chloride, were studied. Content of cholesterol in blood was decreased by 29% and accumulation of cholesterol in liver tissue--by 22% after oral administration of the enterosorbent at a dose of 250 mg/kg into rats with hypercholesterolemia. Cholestyramine exhibited the similar effect only at a dose of 2.

[The effect of water-soluble sorbents on the exocrine function of the liver].

The effect of water-soluble sorbents on exocrine function of the liver was studied in chronic experiments on 2 dogs with a brought out bile duct. It is shown that choline and digitonin sorbents exhibit choleretic properties similar to those of cholestyramine. Choline sorbent causes a drop in the concentration of (2-4-fold) cholic acid in the bile unlike digitonin sorbent.

[A study of hydrolysis of various synthetic peptides with gastrointestinal enzymes using thin-layer chromatography].

Hydrolysis in vitro of alpha- and epsilon-peptide bonds of synthetic amino acids and peptide substrates,--models of protein fragments, with digestive enzymes was studied. The kinetics of hydrolysis was studied by quantitative thin-layer chromatography followed by densitometric analysis of the chromatographic patterns. The rate constants of hydrolysis of Phe-Lys, Gly-Lys dipeptides and their epsilon-acetyl and epsilon-succinyl derivatives with leucine aminopeptidase and pancreatic enzymes were calculated.

[Synthesis and properties of an affinity sorbent for extraction of atherogenic lipoproteins].

A digitonin-containing affinity sorbent was prepared using a hydrophilic polymer carrier. The correlation was found between the polymer structure and crosslink. King degree, on the one hand, and the sorbent capacity to bind cholesterol, protein and lipoproteins--on the other.