[Adenosine triphosphate stress (99m)Tc-MIBI single-photon emission computed tomography in the diagnosis Miocardial Iscemia in patients with Microvascular Angina].

Purpose: To assess diagnostic potential of (99m)Tc-MIBI-single-photon emission computed tomography (SPECT) with intravenous adenosine triphosphate (ATP) infusion in comparison with exercise stress (EX) SPECT in patients with microvascular angina.

Material And Methods: Patients with angina, positive exercise test and normal coronary angiogram (n=25) were included in the study. Patients underwent a three-phase (99m)Tc-MIBI-SPECT scan: at rest, exercise stress test and pharmacological stress with ATP infusion.

[Effects of coronary angioplasty on clinical status, perfusion myocardial contractility in patients with ischemic chronic heart failure].

Chronic heart failure (CHF) remains widespread and prognostically unfavorable complication of various cardiovascular diseases. Most patients with CHF have atherosclerosis of coronary arteries. Main method of treatment of this condition is endovascular revascularization.

[Adenosine triphosphate stress 99mTc-MIBI single-photon emission computed tomography in the diagnosis of ischemic heart disease].

This review is devoted to possibilities of single-photon emission computed tomography (SPECT) combined with pharmacological test with adenosine triphosphate (ATP) to detect myocardial ischemia in patients with ischemic heart disease (IHD). It contains consideration of contemporary problems and limitations inherent in use of pharmacological stress tests in radionuclide diagnostics; discussion of mechanisms of vasodilating effects of ATP in the context of modern concepts of purine receptors; detailed description of technique of pharmacological testing with ATP, as well as contraindications and possible side effects. Experience of foreign studies with the use of ATP stress testing for verification of presence of ischemia in patients with IHD is also presented.

[Perspectives of molecular visualization in cardiology].

The lecture concerns prospects of molecular visualization in cardiology. The term molecular visualization, its aims and problems are characterized Methods of molecular visualization involve such non-invasive techniques as ultrasonic investigation, optic visualization, MR tomography, x-ray CT radionuclide examinations (single photon emission computed tomography and positron-emission tomography). The scope of the above methods and their limits in visualization of biomarker target molecules in different pathological processes on the molecular level, cardiovascular diseases (CVD) are outlined.

[Using nonselective endothelin receptor antagonist in idiopathic pulmonary hypertension].

Idiopathic (primary) pulmonary hypertension (IPH) is a rare disease of unknown etiology, which is characterized by elevated pulmonary artery pressure, increased total pulmonary vascular resistance, frequently a malignant course with evolving right ventricular decompensation, and a fatal outcome. The diagnosis of IPH is established on the increments in the mean resting and exercise pulmonary artery trunk pressure by more than 25 and more than 30 mm Hg at rest and during exercise, respectively, with a normal pulmonary artery wedge pressure. Endothelin receptor antagonists (ERA) are one of the effective classes of drugs for the treatment of patients with IPH.

[The role of multidetector computed tomography in detection of myocardial infarction].

Unlabelled: The aim of the study was to assess the diagnostic value of multidetector computed tomography (MDCT) in detection of myocardial infarction (MI) in acute and chromic stages.

Material And Methods: 49 patients with suspected MI were included in the study. In 44 patients the diagnosis of acute MI had been confirmed according to standard criteria.

[Study of the impact of intramyocardial implantation of stem cells on myocardial perfusion and contractility in patients with coronary heart disease concurrent with postinfarct cardiosclerosis and chronic heart failure].

Objective: to study of intramyocardial implantation of cultured bone marrow stem cells on myocardial perfusion and contractility in the surgical treatment of patients with coronary heart disease (CHD) and chronic heart failure (CHF), by synchronized single-photon emission computed tomography (SSPECT) of the myocardium.

Subjects And Methods: The study included 11 patients. Intramyocardial injection of cell injections into the myocardial periscarring areas was made at coronary bypass surgery.

[QT rate dependence in norm and myocardial infarction].

Aim: To assess QT/RR relationship in healthy subjects and in patients with acute myocardial infarction (AMI) using long term 12-lead ECG monitoring.

Material And Methods: We studied separately diurnal and nocturnal QT interval rate-dependence using a linear model "QT=beta+alphaxRR" in 42 patients with AMI on 2-nd week of the disease and in 14 healthy volunteers. All necessary parameters were automatically calculated from 24-hour 12 lead ECG recordings using special programs.

[Cardiac sympathetic innervation in patients with ventricular arrhythmias: an assessment by 123I-metaiodobenzylguanidine scintigraphy].

The aim of this study was to determine the state of sympathetic innervation in patients with ventricular arrhythmias (VA) using 123I-metaiodobenzylguanidine 123I -MIBG) scintigraphy. Fifty six patients (26 men and 30 women, mean age 37.4+/-11,6) underwent single-photon emission computed tomography (SPECT) imaging and planner scintigraphy after injection of 123I-MIBG (activity 148 MBq).

[Assessment of antianginal and antiischemic effect of trimetazidine and its effects on myocardial perfusion in patients with ischemic heart disease and stable angina.].

Aim: To assess antianginal and antiischemic effects of trimetazidine and its action on myocardial perfusion in patients with ischemic heart disease and stable angina.

Material: Open trimetazidine was given for 3 months to 53 nitroglycerine and beta-blocker treated men aged 47-69 (mean age 60.2+/-0.

[Impairment of cardiac sympathetic function in patients with acute myocardial infarction and unstable angina].

Aim: To assess the state of sympathetic innervation of the heart in patients with acute coronary syndrome.

Material: Patients with Q-myocardial infarction (MI, n=36), non-Q-MI (n=13), and unstable angina (UA, n=9).

Methods: Each subject underwent single-photon emission computed tomography (SPECT) and planar scintigraphy using iodine-123 metaiodobenzylguanidine ((123)I-MIBG) for assessment of cardiac sympathetic function.

[Preliminary data on combined assessment of tolerance to exercise, left ventricular contractile function in ischemic heart disease patients taking bradycardic agents].

Aim: To study effects of bradicardia induced by atenolol, diltiazem and ivabradin on exercise tolerance, myocardial perfusion and left ventricular contractile function in patients with stable angina pectoris.

Material And Methods: The trial included 7 male patients aged 57 +/- 2.6 years with coronary heart disease, stable angina of functional class II free of cardiac failure and severe arterial hypertension, with a positive and reproducible VEM test after therapy discontinuation.

[Evaluation of myocardial perfusion in patients with hypertrophic cardiomyopathy in comparison with clinical and echocardiographic data].

Aim: To study peculiarities of myocardial perfusion in patients with hypertrophic cardiomyopathy (HCMP) in correlation with clinical and echocardiographic data.

Material And Methods: 62 patients with HCMP (23 females and 39 males, mean age 44.4 +/- 11.

[Atenolol induced bradycardia in patients with stable angina: effects on exercise tolerance, myocardial perfusion and left ventricular contractility].

Aim: To assess effects of atenolol-induced heart rate decrease on myocardial perfusion, left ventricular contractility and tolerance to exercise in patients with chronic coronary artery disease.

Material And Methods: Twenty eight men (mean age 54,5-/+9,2 years) with stable class I-III angina and positive reproducible result of bicycle exercise test underwent rest/stress 99mTc-MIIBI gated single-photon emission computed tomography (SPECT) before and after 10 days of administration of atenolol (20 patients) or placebo (8 patients). Dose of atenolol was titrated to achieve at least 15% decrease of heart rate from baseline.

[Strains of Pseudomonas fluorescens 3 and Arthrobacter sp. 2--degradation of polycyclic aromatic hydrocarbons].

Pseudomonas fluorescences 3 and Arthrobacter sp. 2 strains were isolated from the association of microorganisms--destructors of oil hydrocarbons and were selected for their ability to grow on media with phenanthrene as the only source of carbon and energy. The P.

[Myocardial microcirculation in patients with systemic lupus erythematosus].

Aim: To examine myocardial microcirculation in patients with SLE.

Material And Methods: Examination of 21 SLE patients consisted of perfusion tomoscintigraphy of the myocardium with Tl-201 at rest and in combination with bicycle exercise. Various protocols were used.

[Myocardial tomoscintigraphy with 201Tl in the diagnosis of cardiac involvement in systemic scleroderma].

Myocardial microcirculation was assessed in 23 scleroderma systematica patients using 201Tl tomoscintigraphy at rest (23 patients) and upon dipyridamole vasodilation (6 patients). Most patients were found to have impaired blood supply of the myocardium with sites of myocardiofibrosis. In response to dipyridamole introduction improved myocardial perfusion was registered in 4 out of 6 patients, 1 patient showed signs of transient myocardial ischemia, 1 patient had stable defects of myocardial blood supply.

[The myocardial blood supply in chronic alcoholism patients studied by myocardial scintigraphy with 201Tl].

To study myocardial perfusion, 201Tl myocardial scintigraphy was used to examine 25 patients with chronic alcoholism and alcoholic damage to the heart. 201Tl myocardial scintigraphy was performed at rest and repeatedly 3-7 days later by using the bicycle ergometer exercise test. The total 201Tl uptake at rest was 2.

[State of myocardial perfusion in patients with primary hypothyroidism as evidenced by myocardial Tl-201 scintigraphy].

To study the myocardial perfusion in primary hypothyroidism accompanied by cardiac pain feelings, a total of 21 patients aged 30-60 years were examined by using resting 201Tl myocardial scintigraphy and in combination with bicycle ergometric testing. At rest all the patients showed impaired myocardial perfusion. A decrease in 201Tl accumulation, which corresponded to the areas of impaired perfusion, was observed in 54% of segments.

[Clinical and prognostic value of myocardial scintigraphy using technetium Tc 99m pyrophosphate in patients with unstable stenocardia].

The clinical and predictive value of 99mTc pyrophosphate myocardial scintigraphy was studied in 164 patients with various clinical courses of unstable angina pectoris. Some patients with the unstable anginal syndrome proceeding with prolonged pain attacks were shown to have irreversible myocardial lesions detectable by 99mTc pyrophosphate myocardial scintigraphy. However, the study indicated that the presence of small myocardial necrotic foci in this case was of insignificant predictive value.