Publications by authors named "Sammy Villa"
Article Synopsis
- Ribosomes are influenced by ubiquitination and deubiquitination processes, with the deubiquitinase OTUD6 playing a key role in protein translation in Drosophila by modifying the RPS7 subunit of the 40S ribosome.
- Research shows that OTUD6 interacts specifically with the free 40S ribosomes and that several proteins, including RACK1 and E3 ligases like CNOT4 and RNF10, are involved in regulating this interaction and responding to cellular stress.
- The levels of OTUD6 can change due to aging and stress, suggesting it helps control the initiation of protein translation by affecting the recycling of the 40S ribosomes.
Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome.
Mol Biol Cell
September 2021
Mutations in the hedgehog (Hh) signaling are implicated in birth defects and cancers, including medulloblastoma (MB), one of the most malignant pediatric brain tumors. Current Hh inhibitors face the challenge of drug resistance and tumor relapse, urging new insights in the Hh pathway regulation. Our previous study revealed how PDE4D controls global levels of cAMP in the cytoplasm to positively regulate Hh signaling; in the present study, we found that a specific isoform PDE4D3 is tethered to the centrosome by Myomegalin (Mmg), a centrosome/Golgi-associated protein.
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