Publications by authors named "Sammy Hermans"
Pre-eclampsia is a severe placenta-related complication of pregnancy with limited early diagnostic and therapeutic options. Aetiological knowledge is controversial, and there is no universal consensus on what constitutes the early and late phenotypes of pre-eclampsia. Phenotyping of native placental three-dimensional (3D) morphology offers a novel approach to improve our understanding of the structural placental abnormalities in pre-eclampsia.
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- cAMP is a crucial signaling molecule in cells, and its regulation can significantly affect cellular functions; improper signaling can lead to negative outcomes.
- Phosphodiesterase 4 (PDE4) enzymes play a critical role in controlling cAMP levels, with various isoforms modulating signaling in complex, non-linear ways that are challenging to study directly but can be modeled effectively using computational simulations.
- A computational model demonstrated that different PDE4 isoforms distinctly influence cAMP dynamics, highlighting that long PDE4 isoforms have the greatest impact on oscillatory signaling and suggesting that further research should focus on isoform-specific regulation for potential therapeutic advancements.