Publications by authors named "Sammie E Fung"
Purpose: This cross-sectional prospective study measured utility values of upper eyelid dermatochalasis to quantify its impact on quality of life and assess cost-effectiveness of upper blepharoplasty.
Methods: Utility of dermatochalasis was assessed using the standard reference gamble and time trade-off methods, with dual anchor points of perfect eye function and perfect health. The utility value obtained was used to create a Markov model and run a cost-effectiveness analysis of blepharoplasty as a treatment for dermatochalasis while utilizing the societal perspective.
Purpose: To assess whether transcutaneous retrobulbar amphotericin B injections (TRAMB) reduce exenteration rate without increasing mortality in rhino-orbital-cerebral mucormycosis (ROCM).
Methods: In this retrospective case-control study, 46 patients (51 eyes) with biopsy-proven ROCM were evaluated at 9 tertiary care institutions from 1998 to 2021. Patients were stratified by radiographic evidence of local orbital versus extensive involvement at presentation.
Thyroid eye disease reactivation associated with COVID-19 vaccination.
Taiwan J Ophthalmol
February 2022
To describe the presentation of both new-onset and reactivation of thyroid eye disease (TED) following COVID-19 vaccination. Single-institution retrospective case series of patients presenting with symptoms and signs of new or reactivated TED coinciding with recent COVID-19 vaccination. Data collected included patient age, gender, presenting symptoms, ocular history, clinical signs, and interval duration between vaccination and onset of ocular symptoms.
View Article and Find Full Text PDFNeurotrophic keratopathy is a degenerative disease in which damage to the corneal nerves leads to corneal hypoesthesia. Injuries to neurotrophic corneas are notoriously difficult to treat and have traditionally been approached with supportive management. However, recent progress in the field of corneal neurotization has given new direction for addressing nerve loss directly by stimulating new nerve growth onto the cornea from nearby sensory nerves transferred to the perilimbal region.
View Article and Find Full Text PDFArticle Synopsis
- - The CDC identifies multidrug resistant Acinetobacter baumannii as an "urgent threat" due to its ability to cause severe infections like pneumonia and meningitis, particularly after neurosurgery, where it's difficult to treat.
- - The study investigates how A. baumannii adapts to the cerebrospinal fluid (CSF), revealing that certain genetic changes allow it to persist in nutrient-limited environments and enhance virulence factors like fimbriae and iron chelators, especially in low-virulence strains.
- - Findings show that while hypervirulent strains maintain stable gene expression in CSF, low-virulence strains exhibit significant changes; additionally, human serum albumin in CSF influences the expression of genes crucial for