Should all pregnant women take calcium supplements in Nepal? GRADE evidence to policy assessment.

Background: The WHO recommends oral calcium supplementation (1.5-2.0 g) in pregnant women to reduce the risk of pre-eclampsia living in areas with low dietary calcium intake.

Targeting Cancer Stem Cells: Therapeutic and diagnostic strategies by the virtue of nanoparticles.

Cancer stem cells (CSCs) are the subpopulation of cells present within a tumor with the properties of self-renewing, differentiating, and proliferating. Owing to the presence of ATP-binding cassette drug pumps and increased expression of anti-apoptotic proteins, the conventional chemotherapeutic agents have failed to eliminate CSCs resulting in relapse and resistance of cancer. Therefore, to obtain long-lasting clinical responses and avoid the recurrence of cancer, it is crucial to develop an efficient strategy targeting CSCs by either employing a differentiation therapy or specifically delivering drugs to CSCs.

Is routine Vitamin A supplementation still justified for children in Nepal? Trial synthesis findings applied to Nepal national mortality estimates.

Background: The World Health Organization has recommended Vitamin A supplementation for children in low- and middle-income countries for many years to reduce child mortality. Nepal still practices routine Vitamin A supplementation. We examined the potential current impact of these programs using national data in Nepal combined with an update of the mortality effect estimate from a meta-analysis of randomized controlled trials.

Spatial access to sport facilities from the multiple places visited and sport practice: Assessing and correcting biases related to selective daily mobility.

Background: Studies investigating the association between spatial accessibility to environmental resources from the various places a person visits during daily activities and use of corresponding resources often do not account for potential biases related to selective daily mobility. This bias occurs when accessibility is also measured from places intentionally visited to access the resources of interest. The aim of this study was to examine associations between spatial accessibility to sports facilities from multiple places and sport practice while addressing the selective daily mobility bias.