Publications by authors named "Samiya Abi-Jaoude"
Article Synopsis
- PIK3CA mutations in meningiomas are rare but significant, suggesting they may be potential targets for therapy due to their occurrence in both benign and malignant tumors, including those influenced by hormones.
- Researchers used genetically engineered mouse models to show that these mutations in meningeal cells can lead to the formation and progression of meningiomas, while hormone exposure alone does not trigger tumor growth in this context.
- The study also revealed that while hormone presence increases mutation burden in PIK3CA-mutant conditions, it primarily drives breast tumor formation rather than meningioma development, highlighting the dominant role of PIK3CA mutations in meningioma tumorigenesis.
Objective: Based on their clinical and radiological patterns, idiopathic CSF rhinorrhea and idiopathic intracranial hypertension can represent different clinical expressions of the same underlying pathological process. Transverse sinus stenoses are associated with both diseases, resulting in eventual restriction of the venous CSF outflow pathway. While venous sinus stenting has emerged as a promising treatment for idiopathic intracranial hypertension, its efficiency on idiopathic CSF leaks has not been very well addressed in the literature so far.
View Article and Find Full Text PDFBackground: Cerebral cavernous malformations (CCMs) are common sporadic and inherited vascular malformations of the central nervous system. Although familial CCMs are linked to loss-of-function mutations in (), , or (), the genetic cause of sporadic CCMs, representing 80% of cases, remains incompletely understood.
Methods: We developed two mouse models harboring mutations identified in human meningiomas with the use of the prostaglandin D2 synthase (PGDS) promoter.
Hormone-associated meningiomas tend to stop growing or decrease in size after cessation of certain progestins, mainly cyproterone acetate. We report three observations on the natural history of hormone-associated intraosseous meningiomas, showing in a first patient that those tumors may grow rapidly under nomegestrol. We then demonstrate the sustained growth of intraosseous hormone-associated meningiomas after cessation of promesgestone and nomegestrol, independently of the intracranial portion, which concurrently decreased in size in the second case or was resected at the time of nomegestrol withdrawal in the third case, thus giving new insights into the tumorigenesis mechanisms of hormone-associated intraosseous meningiomas.
View Article and Find Full Text PDFPurpose: Middle meningeal artery (MMA) embolization is emerging as a potential treatment of chronic subdural hematomas (CSDHs). The purpose of this study is to describe MMA angiographic anatomy in relation to CSDH embolization.
Methods: This retrospective monocentric study was performed on imaging data of MMA embolization procedures for CSDH treatment performed between March 15, 2018 and April 30, 2020.
Objective: Intracranial meningiomas occur in about half of neurofibromatosis type 2 (NF2) patients and are very frequently multiple. Thus, estimating individual meningiomas' growth rates is of great interest to tailor therapeutic interventions. The Asan Intracranial Meningioma Scoring System (AIMSS) has recently been published to estimate the risk of tumor growth in sporadic meningiomas.
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