Publications by authors named "Samira Slimani"
Article Synopsis
- * Recent research has focused on understanding how these bone cells grow and change, aiming to identify targets for new treatments.
- * Cation-Cl cotransporters (CCCs) are important ion transport systems in bone cells that influence calcium and phosphate transport, yet they have received limited attention despite their potential role in treating bone-related conditions.
Article Synopsis
- The loop of Henle is crucial for regulating extracellular fluid volume, blood pressure, and maintaining levels of Ca, Mg, and acid-base balance by reabsorbing a significant portion of filtered solutes.
- It contributes to urinary concentration by creating an osmotic gradient from the kidney's cortex to medulla, essential for water reabsorption.
- The article explores the loop's functions, molecular processes, and new research findings, emphasizing its relevance in the context of SGLT2 inhibitors and kidney health.
Article Synopsis
- * Recent cryo-EM studies of human KCC3b and KCC1 revealed structural details of how phosphorylation influences their function and transport activity.
- * The research identifies new phosphorylation sites and an unexpected ATP/ADP-binding pocket, paving the way for potential drug development targeting KCC regulation.
Article Synopsis
- NKCC2 is an important membrane protein found in the nephron, particularly in the thick ascending loop of Henle, that helps move sodium, potassium, and chloride ions across cell membranes.
- It plays a crucial role in the kidney's ability to reabsorb essential ions and minerals like sodium, calcium, and magnesium, which are vital for maintaining electrolyte balance.
- The presentation will discuss NKCC2's physiological functions, molecular traits, and the implications of its dysfunction, including the effects of diuretics and genetic disorders on kidney health.
Article Synopsis
- NKCC2 is a membrane protein found in the thick ascending limb of Henle that helps in reabsorbing sodium and chloride and has three splice variants with different transport functions and characteristics.
- Recent research shows that these variants also have different trafficking properties, with specific residues in exon 4 influencing their behavior in cells.
- The study highlights a novel role for alternatively spliced exons in NKCC2, revealing important information about cation-Cl cotransporters and how they manage protein localization and internalization in response to cellular changes.
Article Synopsis
- NKCC2 is a specialized cotransporter found in the kidneys that plays a crucial role in reabsorbing sodium and chloride ions, and it exists in three main variants (NKCC2A, NKCC2B, NKCC2F) with slight differences in their structure.* -
- This study uses an experimental system to show that cell shrinkage can enhance the activity of NKCC2A and NKCC2B by increasing their presence on the cell surface, a process that may involve WNK kinases.* -
- In contrast, NKCC2F was less responsive to cell shrinkage, indicating that different NKCC2 variants have unique regulatory mechanisms, highlighting the importance of a specific domain in their function