Environmental exposure to titanium dioxide nanoparticles disrupts DAZL gene expression and male reproductive function in mice: Protective role of lutein.

Titanium dioxide nanoparticles (TiO NPs) are widely used nanomaterials with potential environmental health concerns, including impacts on male fertility. This study investigated the effects of TiO NPs on male reproductive function in mice and the potential protective role of lutein, a dietary antioxidant. Male NMRI mice were exposed to TiO NPs (50, 150, and 300 mg/kg) with or without co-administration of lutein (5 or 10 mg/kg) for 35 days.

Comparative study of radioprotective effects of endurance training in irradiation-induced nephropathy of rat model.

Objectives: Considering the antioxidant properties of endurance training, this study aimed to investigate the effects of endurance training on serum levels of oxidative stress and structural changes in the kidney tissue of rats exposed to X-ray irradiation.

Methods: In this experimental study, 24 rats weighing 220±20 g were randomly divided into four groups (healthy control, healthy with moderate-intensity continuous training, X-ray control, and X-ray with moderate-intensity continuous training). The two groups of rats were irradiated with 4 Gy X-rays.

Comparing the acute and chronic effects of metformin and antioxidant protective effects of N-acetyl cysteine on memory retrieval and oxidative stress in rats with Alzheimer's disease.

It has been suggested that oxidative stress plays an important role in neural degeneration and Alzheimer's disease. Some studies have shown that metformin has some beneficial effects on the brain and reduces oxidative stress, while others reveal that metformin increases oxidative stress in diabetic patients. In this study acute and chronic effects of metformin and antioxidant protective effects of N-acetyl cysteine in Alzheimeric rats were investigated.