Mode of binding, kinetic and thermodynamic properties of a lipid-like drug (Fingolimod) interacting with Human Serum Albumin.

Fingolimod is a drug that is used to treat multiple sclerosis (MS). It has pH-dependent solubility and low solubility when buffering agents are present. Multi-spectroscopic and molecular modeling methods were used to investigate the molecular mechanism of Fingolimod interaction with human serum albumin (HSA), and the resulting data were fitted to the appropriate models to investigate the molecular mechanism of interaction, binding constant, and thermodynamic properties.

Pregnancy outcomes following the administration of high doses of dexamethasone in early pregnancy.

Objective: In the present study, we aimed to evaluate the effects of high doses of dexamethasone (DEX) in early pregnancy on pregnancy outcomes.

Methods: Pregnant BALB/c mice were treated with high-dose DEX in the experimental group or saline in the control group on gestational days (GDs) 0.5 to 4.

3-(Amino-carbon-yl)pyridinium diaqua-bis-(pyridine-2,6-dicarboxyl-ato)bis-muthate(III) monohydrate.

The asymmetric unit of the ionic title compound, (C(6)H(7)N(2)O)[Bi(C(7)H(3)NO(4))(2)(H(2)O)(2)]·H(2)O or (acpyH)[Bi(pydc)(2)(H(2)O)(2)]·H(2)O, contains an [Bi(pydc)(2)(H(2)O)(2)](-) anion (where pydcH(2) is pyridine-2,6-dicarb-oxy-lic acid), a protonated 3-(amino-carbon-yl)pyridine as counter-ion, (acpyH)(+), and one uncoordinated water mol-ecule. The anion is an eight-coordinate complex with a square-anti-prismatic geometry around the Bi(III) atom. In the crystal, extensive O-H⋯O and N-H⋯O hydrogen bonds, as well as ion pairing, C=O⋯π inter-actions [O⋯centroid distance = 3.