Allopurinol for fibromyalgia pain in adults: A randomized controlled trial.

Background: Allopurinol is a potent inhibitor of the enzyme xanthine oxidase used in the treatment of hyperuricemia and gout. Because it is well known that purines exert multiple affects on pain transmission, we hypothesized that the inhibition of xanthine oxidase by allopurinol could be a valid strategy to treat pain in humans. This study aimed to compare the analgesic efficacy of oral allopurinol versus placebo as an adjuvant therapy in patients displaying fibromyalgia.

Pneumonia during the first two years of life does not increase risk of respiratory infections in preschool children.

Summary Objectives: To investigate the relationship between severe pneumonia during the first two years of life and subsequent respiratory infections in preschool children.

Methods: This was a cross-sectional study. We interviewed parents of children who were classified as exposed (n = 36) or non-exposed (n = 84), based on whether they were hospitalized with radiologically-confirmed pneumonia during the first two years of life.