Publications by authors named "Samira Fatmi"
The Endothelial Activation and Stress Index (EASIX) is a prognostic tool that uses common clinical laboratory values and has been shown to predict non-relapse mortality (NRM) and overall survival (OS) at the onset of acute graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). We hypothesized that EASIX calculated at different time points pre- and post- HCT may predict NRM and OS, and that EASIX calculated at onset of GVHD may predict response to steroids. We evaluated the EASIX score pre- and post-HCT in 152 patients with lymphoid malignancies undergoing unmodified reduced intensity conditioning (RIC) alloHCT with uniform GVHD prophylaxis.
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- Graft-versus-host disease (GVHD) is a serious condition that can occur after stem cell transplants and often leads to complications.
- A study was conducted to evaluate the safety and effectiveness of F-652, a new treatment involving interleukin-22 combined with corticosteroids for patients with acute lower gastrointestinal GVHD.
- Results showed that 70% of patients responded positively to the treatment, with improvements in gut microbiota composition, indicating a potential new strategy to support healing and manage this condition.
GVHD is a frequent complication following allo-HCT. The NIH consensus group established new guidelines for the evaluation of chronic GVHD. However, GVHD assessment remains challenging due its complexity and requirement for laborious evaluation.
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