Publications by authors named "Samira Ali Abbas"
Background: Hemolysis due to ABO incompatibility is an important differential diagnosis in newborns presenting with jaundice. Clinical studies evaluating ABO hemolytic disease of fetus and newborn (ABO-HDFN) question the diagnostic value of the direct antiglobulin test (DAT) in this situation.
Goals: To determine the clinical and laboratorial findings associated with the occurrence of ABO-HDFN and to evaluate the accuracy of DAT as a diagnostic tool.
Article Synopsis
- The study focuses on two cases of maternal anti-Fc-gamma-receptor-IIIb isoimmunization that did not show neonatal alloimmune neutropenia (NAIN) symptoms, highlighting the necessity of neutrophil isolation for diagnosing autoimmune conditions.
- Researchers compared two neutrophil isolation methods: immunomagnetic negative selection (IMNS) and traditional dextran/Ficoll, finding IMNS significantly produced more neutrophils in less time, despite being costlier.
- The findings underscore the importance of recognizing asymptomatic cases that could lead to severe neutropenia and validate IMNS as a superior method for neutrophil isolation in serological assays.
Objective: To compare the incidence of small for gestational age infants among late preterm and term newborns, using the Fenton and Intergrowth-21st curves.
Methods: Observational and retrospective study with newborns in a level II maternity. The study was approved by the Institution's Ethics Committee.
Article Synopsis
- The study aimed to analyze the blood profiles of late preterm and term newborns, focusing on how factors like sex, weight for gestational age, and delivery method affect hematological indices.
- It included 2,662 newborns, finding that premature infants typically had lower blood cell counts, while small for gestational age (SGA) infants showed higher hemoglobin and hematocrit levels but lower leukocyte counts.
- It concluded that while most blood cells increased with gestation, males and SGA infants presented unique blood characteristics, particularly regarding platelet counts which were affected by delivery method and maternal health issues like hypertension.
Background: Neonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5a; however, to date, antibodies specific to HNA-3b have not been reported.
Study Design And Methods: Blood samples from 10,000 unselected neonates were analyzed, resulting in the selection of 88 neutropenic newborns (neutrophil count <1.