Aloe arborescens Standardized Glycosidic Fraction Suppresses Hepatocarcinoma by Modulating TIMP1, MMP9 Genes Expression, and Inflammation/Ki67/TGFβ1 Pathway.

(1) Background and aim: Aloe arborescens Mill. (A. arborescens) is one of the most widely distributed species in the genus Aloe and has garnered widespread recognition for its anticancer properties.

Adsorption of cationic dye onto Raphanus seeds: optimization, adsorption kinetics, thermodynamic studies.

Dyes are one of the common contaminants in industrial wastewater. Adsorption is the most widely method which used to treat dye-contaminated water due to their easy use, cost-effectiveness, and their efficiency was high. The aim of this study is the investigating of the utilization of the activated carbon which prepared from Raphanus seeds solid residual (ACRS) as a low cost adsorbent for removing of cationic Methylene Blue dye (MB)from wastewater.

Peel Essential Oil Ameliorates Potassium Dichromate-Induced Lung Injury: Insights into the PI3K/AKT Pathway.

Acute Lung Injury (ALI) is a life-threatening syndrome that has been identified as a potential complication of COVID-19. There is a critical need to shed light on the underlying mechanistic pathways and explore novel therapeutic strategies. This study aimed to examine the potential therapeutic effects of essential oil (CCEO) in treating potassium dichromate (PDC)-induced ALI.

The detrimental impact of high environmental temperature on physiological response, growth, milk production, and reproductive efficiency of ruminants.

The optimal environments for ruminants are air temperatures between 13 and 20 °C, winds between 5 and 18 km/h, humidity levels between 55 and 65%, and a moderate amount of sunlight. In tropical and subtropical regions, climate is the top factor restricting animal growth and reproductive efficiency. The digestive system, blood biochemical components, and hormones all go through a range of physiological changes at high temperatures.

The Impact of Sociodemographic, Nutritional, and Health Factors on the Incidence and Complications of COVID-19 in Egypt: A Cross-Sectional Study.

This study was intended to explore sociodemographic, nutritional, and health-related factors on the incidence of COVID-19 infection within the Egyptian population by assessing the frequency and determinants of post-COVID-19 symptoms and complications. A cross-sectional study using a structured survey on 15,166 participants was adopted. The results revealed common symptoms including fever (79.

Increased signal intensity with delayed post contrast 3D-FLAIR MRI sequence using constant flip angle and long repetition time for inner ear evaluation.

Purpose: The purpose of this study was to compare the degree of perilymphatic enhancement between 4 hour post-contrast constant flip angle three-dimensional fluid attenuated inversion recovery (3D-FLAIR) images obtained with short repetition time (TR) and those obtained with long TR.

Materials And Methods: This single-center, prospective study included patients who underwent MRI of the inner ear with heavily T2-weighted sequence, 3D-FLAIR sequence with a "short" TR of 10,000 ms (s3D-FLAIR) and with a "long" TR of 16,000 ms (l3D-FLAIR). Signal intensity ratio (SIR) and contrast-to-noise ratio (CNR) obtained with s3D-FLAIR and l3D-FLAIR were quantitatively assessed using region of interest (ROI) method and compared.

Characterization, Antimicrobial and Anticancer Properties of Palladium Nanoparticles Biosynthesized Optimally Using Saudi Propolis.

Due to their unique physicochemical characteristics, palladium nanoparticles (Pd-NPs) have shown tremendous promise in biological applications. The biosynthesis of Pd-NPs employing Saudi propolis has been designed to be environmental, fast, controlled, and cost-effective. The formation and stability of biosynthesized Pd-NPs by Saudi propolis extract were proved by ultraviolet-visible spectrophotometry (UV-Vis), Fourier-transform infrared spectroscopy (FT-IR), and Zeta potential analysis.

Antioxidant, Anti-Inflammatory and Cytotoxic Activities of (Burm. F.) Andrews Leaves towards MCF-7 Breast Cancer and HCT 116 Colorectal Cell Lines and Identification of Bioactive Metabolites.

Background: The plants of high phenolic contents are perfect antioxidant and anti-inflammatory agents and participate in biological studies as effective agents towards different cancer cell lines.

Objective: To investigate the antioxidant, anti-inflammatory, and cytotoxic activities of the hydromethanolic leaf extract of Jasminum multiflorum (Burm. f.

The role of active metabolites isolated from flowers against hepatitis C virus infection and related hepatocellular carcinoma.

Jasminum Burm. f. ( is an ornamental plant with traditional medicinal importance.

Green Synthesis of Silver Nanoparticles Using Extract of L. Leaves and Evaluation of Cytotoxic Activity Towards Bladder (5637) and Breast Cancer (MCF-7) Cell Lines.

Introduction: L. is a very important medicinal and industrial flowering aromatic plant.

Methods: The present study deals with L.

Aldose reductase inhibitor form Cassia glauca: A comparative study of cytotoxic activity with Ag nanoparticles (NPs) and molecular docking evaluation.

UPLC-MS/MS profiling of Cassia glauca leaves extract revealed the identification of 10 flavonoids. Kaempferol 3-O-β-D-rutinoside was isolated and studied for its cytotoxic activity. It showed high cytotoxic effects against MCF-7 (IC50 of 4.

L. leaves: HPLC-PDA/MS/MS profiling and cytotoxicity supported by molecular docking.

In this study chemical profiling of L. () using HPLC-PDA/MS/MS and evaluation of its cytotoxicity towards the human breast cancer cell line (MCF-7), human colorectal cancer cell (HCT-116) and human hepatocellular carcinoma (Huh-7) cell lines. The viability % was determined by the neutral red uptake assay.

Phenolic profiling of different species cultivated in Egypt and their antioxidant activity.

This study focused on the profiling of phenolic constituents in 80% methanolic extracts of the leaves of some species cultivated in Egypt and their antioxidant activities. Phenolic profiling was performed by total phenolic contents, total flavonoid contents and HPLC-DAD for selected species in comparison to authentic standards. DPPH assay was used to estimate the antioxidant activities of L.

A highly sensitive GC-MS method for simultaneous determination of anacardic acids in cashew (Anacardium occidentale) nut shell oil in the presence of other phenolic lipid derivatives.

The commercial value of cashew nut shell liquid (CNSL) has become a cornerstone of the agrowaste industry. It is the by-product of the cashew industry and has an 1/8 inch thickness of soft honeycomb structure. CNSL contains phenolic lipids with aliphatic chains such as anacardic acid, cardanol, cardol and methyl cardol, and their derivatives.

Chemical profiling of secondary metabolites of Eugenia uniflora and their antioxidant, anti-inflammatory, pain killing and anti-diabetic activities: A comprehensive approach.

Ethnopharmacological Relevance: The red Brazilian cherry, Eugenia uniflora, is widely used in traditional medicine. The aim of this study was to investigate the phytochemical composition of a methanol extract from leaves of E. uniflora and characterization of the isolated compounds.

Isolation of Myricitrin and 3,5-di-O-Methyl Gossypetin from and Evaluation of their Involvement in Protecting Keratinocytes against Oxidative Stress via Activation of the Nrf-2 Pathway.

The wax apple () is traditionally employed as an antibacterial and immunostimulant drug in traditional medicine. This plant is rich in different flavonoids and tannins. In this study, we isolated two compounds from leaves: myricitrin and 3,5-di--methyl gossypetin.

Chemical composition, antioxidant and hepatoprotective activities of methanol extracts from leaves of and (Combretaceae).

Background: Plants belonging to the genus such as and are used traditionally to treat several diseases and health disorders. Up to this date, the roots of and the fruits of are the mostly studied plant parts. The phytochemical composition and the biological activities of the leaves of both species are not well identified so far.

A New Polyoxygenated Flavonol Gossypetin-3---d-Robinobioside from (Hook.) D. Dietr. and In Vivo Hepatoprotective, Anti-Inflammatory, and Anti-Ulcer Activities of the Leaf Methanol Extract.

A hitherto unknown polyoxygenated flavonol robinobioside (gossypetin-3---d-robinobioside) was isolated from the leaves of along with thirteen known phenolic secondary metabolites. The isolated compounds were characterized using spectroscopic analysis, including 1D and 2D NMR and mass spectrometry (MS) analyses. The extract reduced the level of liver damage in CCl₄-induced liver injury in rats.

Rheum palmatum root extract inhibits hepatocellular carcinoma in rats treated with diethylnitrosamine.

Objectives: The aim of this study was to investigate the potential anticancer properties of a methanol extract of Rheum palmatum roots against diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats and to characterize its phytoconstituents.

Methods: HPLC-PDA-MS/MS was used to profile the secondary metabolites in R. palmatum root extract.

Cytotoxic constituents from subsp. seeds.

Chemical investigation of  subsp.  Retz. revealed isolation of one new hydroxy- fatty acid () identified as (6-, 10-)-9-hydroxy henicosa-6,10-dienoic acid in addition to six known metabolites; hexadecanoic acid (), β-sitosterol (), β-amyrin (), β-sitosterol-glucoside (), 2,3-dihydroxypropyl tetradecanoate () and (Z)-9-hydroxypentadec-6-enoic acid ().

Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract.

Context: Terminalia muelleri Benth. (Combretaceae), is rich with phenolics that have antioxidant and cytotoxic activities. No screening studies were published before on T.

A New Octadecenoic Acid Derivative from Caesalpinia gilliesii Flowers with Potent Hepatoprotective Activity.

Background: Caesalpinia gilliesii Hook is an ornamental shrub with showy yellow flowers. It was used in folk medicine due to its contents of different classes of secondary metabolites. In our previous study, dichloromethane extract of C.

New Isorhamnetin Derivatives from Salsola imbricata Forssk. Leaves with Distinct Anti-inflammatory Activity.

Background: Salsola imbricata Forssk. is a shrub widely growing in Egypt, used as a camel food, traditionally, used as anti-inflammatory agent. Literature survey showed no report about the anti-inflammatory activity of S.

A new pregnane glycoside from Gomphocarpus fruticosus growing in Egypt.

Phytochemical investigation of Gomphocarpus fruticosus (L.) Ait. of Egyptian origin afforded the new pregnane glycoside lineolon-3-O-[β-D-oleandropyranosyl-(1-4)-β-D-cymaropyranosyl-(1-4)-β-D-cymaropyranoside], along with six known compounds.