Publications by authors named "Samir M Awadallah"
Background: Increased oxidative stress and impaired antioxidative capacity are common findings in diabetics. This study reports on the status of antioxidative enzymes in relation to haptoglobin (Hp) polymorphism in type 2 diabetes.
Methods: The study comprised 165 type 2 diabetic patients and 94 controls.
Background: Ischemia modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress. This study reports on the levels and clinical significance of IMA in patients with β-thalassemia major.
Methods: Blood specimens were collected from 166 subjects (101 β-thalassemia major patients and 65 healthy controls).
Background: Haptoglobin (Hp) and ceruloplasmin (CP) are 2 plasma antioxidants playing a role in preventing iron-induced oxidative damage. This study presents data related to Hp phenotypes and ceruloplasmin ferroxidase activity in relation to iron store markers in patients with β-thalassemia major.
Methods: Blood specimens were collected from 196 subjects (124 β-thalassemia major patients and 72 healthy controls).
Background: Recent studies have suggested an inheritable influence of haptoglobin phenotypes on the development of microalbuminuria in diabetic patients. In this study, we aimed to investigate whether microalbuminuria and serum levels of Cystatin C (Cys C) were correlated with haptoglobin phenotypes in patients with Type 2 diabetes mellitus.
Methods: Fasting blood samples and first morning urine specimens were collected from 216 patients with type 2 diabetes (mean age 60.
Background: Ceruloplasmin (CP) has been suggested to play a role in the oxidative modification of LDL. The correlation between autoantibodies against oxidized LDL (anti-oxLDL), markers of oxidative stress, and the concentration of CP has not been previously investigated. We examined the status of these parameters in patients with myocardial infarction (MI) and stable angina.
View Article and Find Full Text PDFObjective: To assess, in vitro, the effect of Amifostine (AMF, WR-2721) on angiogenesis and levels of vascular endothelial growth factor (VEGF) secreted from hemopoietic stem/progenitor cell populations.
Methods: We conducted the study in the research laboratories of the Hashemite University, Jordan between September 2003 and January 2005 where we took samples were from Myelodysplastic syndrome (MDS) patients and healthy donors attending Al-Hussein Cancer Center and We determined the proliferation of human umbilical vein endothelial cells (HUVECs) in cultures supplemented with media conditioned with AMF-treated and AMF-untreated pure hemopoietic cells [CD34+ cells, and erythroid, myeloid and megakaryocytic progenitors]. Furthermore, in the same conditioned media, we evaluated levels of elaborated VEGF by a sensitive enzyme linked immunosorbent assay.
Background: Previous reports regarding the occurrence of breast cancer and its association with Hp polymorphism are conflicting. The possible role of family history as a factor in determining the degree of association between the disease and Hp polymorphism has not been reported before. In this study, the distribution of haptoglobin phenotype among patients with familial and nonfamilial breast cancer was investigated.
View Article and Find Full Text PDFHaptoglobin 2-2 phenotype is associated with decreased ferroxidase activity in smokers.
Clin Chim Acta
August 2003
Background: Cigarette smoking and the inheritance of Hp 2-2 phenotype have been separately linked to cardiovascular disease. In this study, the combined effects of smoking and the presence of Hp 2-2 type on predisposition to cardiovascular disease were investigated.
Methods: Fasting blood specimens were collected from 489 Jordanian males (228 smokers and 261 nonsmokers).