Publications by authors named "Samir Jaawan"
Article Synopsis
- Phospholamban (PLN) is a protein that plays a crucial role in heart muscle function by regulating calcium levels, and a specific mutation (R14Δ-PLN) leads to severe heart muscle disease that doesn't respond well to standard treatments.
- Researchers are using a technique called complexome profiling (CP) to analyze how this mutation affects protein complexes in the hearts of mice, but existing methods face challenges because most data is based on cancer cells rather than heart cells.
- To overcome this, a new analysis approach named PERCOM was developed, which identified 296 proteins with altered behaviors in mutant heart tissue, particularly affecting mitochondrial and intercalated disk supercomplexes.
