Analysis of Two Oncological Drugs Futibatinib and Capivasertib via Ion-Pairing With Eosin Y as a Spectrofluorimetric and Spectrophotometric Probe.

Using spectroscopy, two quick and sensitive analytical methods based on eosin Y ion pairing were developed and assessed in order to determine capivasertib and futibatinib with high selectivity and sensitivity. The quenching impact of futibatinib or capivasertib on the eosin Y's fluorescence at a pH 3.8 and 3.

Correction: Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models.

[This corrects the article DOI: 10.1371/journal.pone.

Spach. protects against acetaminophen-induced liver failure via preserving the glutathione redox system, reducing inflammatory response, and inhibiting hepatocyte death in rats.

Objectives: The current study was conducted to assess the protective mechanisms of BuOH fraction from the aerial part of (BEGC) on APAP-induced liver injury compared to necrostatine-1 (Nec-1).

Materials And Methods: A model of APAP-induced hepatotoxicity was created in male rats by injecting a single dose; 1000 mg/kg APAP, the protective effect was performed with (200 mg/kg; 10 days) BEGC compared to Nec-1, (1.8 mg/kg).

Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer.

Skin cancer is a widespread type of cancer representing 30% of all cancer types worldwide. Resveratrol (RSV) is an anticancer drug used for skin cancer treatment. Several limitations of RSV such as poor aqueous solubility, first-pass metabolism, and instability limit their topical use.

Successful removal of fluoride from aqueous environment using Al(OH)@AC: column studies and breakthrough curve modeling.

In this study, we discuss the removal of fluoride from water through column adsorption methods using Al(OH)@AC as a functional granular activated carbon. The height of the bed, fluoride concentration, and flow rate are the experimental factors used to obtain the breakthrough curves. As the flow rate increased, the breakthrough and saturation times decreased.

Hypovitaminosis D in Haematological Malignancies: Cause or Consequence?

Vitamin D is a pleiotropic hormone, widely controversial for its role in the development of chronic diseases and cancers, including haematological malignancies, and also for its impact on overall survival. Observational and interventional studies are being conducted on hypovitaminosis D and haematological malignancies and their subtypes in order to improve the therapeutic management of patients. We carried out a prospective observational study over three years on a population of 251 patients followed up for newly diagnosed haematological malignancies to investigate the impact of vitamin D deficiency on this category of patients.

Herbs carbonization and activation for fast sorption of nitrate ions: a new challenge for a full treatment of groundwater pollution.

The evolution of low-cost ecotechnologies in water treatment and purification is highly increased. Face to the growing global demand for eco-friendly water treatment materials, the non-valorized herb-based biomass covering a large area could be a promising alternative. Herbs (HB) are currently one of the cheapest biomasses.

Atypical anti-NMDA receptor encephalitis associated with varicella zoster virus infection.

The triggering effect of herpes simplex virus infection on the development of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is now well established. However, there are very few reports that has linked a varicella zoster virus (VZV) reactivation with anti-NMDAR encephalitis. In this report, we describe a case of a 57-year-old man presented with atypical clinical presentation of anti-NMDAR encephalitis with gait ataxia, complete ophtalmoplegia, and abolished reflexes followed by drowsiness and confusion.

Effect of pre and post-transplant body mass index on pediatric kidney transplant outcomes.

Introduction: Kidney transplantation (KT) has been established as an efficient treatment of end stage renal disease (ESRD) with the advantage of allowing the patient to live a nearly healthy life. We aimed to determine whether pre-transplant body mass index (BMI) affects renal allograft function and survival in pediatric KT recipients.

Methods: cross sectional cohort study included 50 post KT recipients (more than 3 years) with an age range of 10 to 15 years, regularly following at the Kidney Transplantation Outpatient Clinic, Cairo University Children's Hospital, were subjected to a detailed history and physical examination, laboratory investigation in the form of fasting blood glucose (FBG),oral glucose tolerance test (OGTT), lipid profile, hemoglobin A1c (HbA1c) and microalbuminuria.

Functional activated carbon: from synthesis to groundwater fluoride removal.

Developing green and functional adsorbents for the removal of inorganic pollutants from industrial wastewater is still a great challenge. Activated carbons (ACs) are promising eco-friendly materials for adsorption applications. This study reports on the preparation and functionalization of AC and its application for fluoride removal from water.

Advances in Amine-Surface Functionalization of Inorganic Adsorbents for Water Treatment and Antimicrobial Activities: A Review.

In the last decade, adsorption has exhibited promising and effective outcomes as a treatment technique for wastewater contaminated with many types of pollutants such as heavy metals, dyes, pharmaceuticals, and bacteria. To achieve such effectiveness, a number of potential adsorbents have been synthesized and applied for water remediation and antimicrobial activities. Among these inorganic adsorbents (INAD), activated carbon, silica, metal oxide, metal nanoparticles, metal-organic fibers, and graphene oxide have been evaluated.

Malnutrition score and Body Mass Index as nutritional screening tools for hemodialysis patients.

Background And Aims: Malnutrition is highly prevalent in the hemodialysis population. Nutritional screening is important to identify patients at risk of malnutrition. This study aimed to investigate the concurrent validity of BMI cut-offs (BMI < 23 kg/m and BMI < 18.

Correction: Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models.

[This corrects the article DOI: 10.1371/journal.pone.

Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models.

Two novel and highly accurate hybrid models were developed for the prediction of the flammability limits (lower flammability limit (LFL) and upper flammability limit (UFL)) of pure compounds using a quantitative structure-property relationship approach. The two models were developed using a dataset obtained from the DIPPR Project 801 database, which comprises 1057 and 515 literature data for the LFL and UFL, respectively. Multiple linear regression (MLR), logarithmic, and polynomial models were used to develop the models according to an algorithm and code written using the MATLAB software.

Gas-phase UV absorption spectra and OH-oxidation kinetics of 1-1,2,3-triazole and pyrazole.

In this work, we report the gas phase UV absorption spectra and the kinetics of the OH-oxidation of 1-1,2,3-triazole and pyrazole. UV spectra were determined between 200 and 250 nm, at 350 ± 2 K and at pressures between 0.09 and 0.

Prevalence and risk factors for patient-reported joint pain among patients with HIV/hepatitis C coinfection, hepatitis C monoinfection, and HIV monoinfection.

Background: To determine the prevalence of patient-reported joint pain among patients with human immunodeficiency virus (HIV)/chronic hepatitis C virus (HCV) coinfection, chronic HCV monoinfection, and HIV monoinfection followed in hepatology and infectious disease outpatient practices.

Methods: Standardized interviews were performed among 79 HIV/HCV-coinfected, 93 HCV-monoinfected, and 30 HIV-monoinfected patients in a cross-sectional study within hepatology and infectious disease clinics at three centers. The Multi-Dimensional Health Assessment Questionnaire was used to ascertain joint pain and associated symptoms.

The European Medicines Agency approval of ingenol mebutate (Picato) for the cutaneous treatment of non-hyperkeratotic, non-hypertrophic actinic keratosis in adults: summary of the scientific assessment of the Committee for Medicinal Products for Human Use (CHMP).

Background: The European Commission has recently issued a marketing authorisation valid throughout the European Union for ingenol mebutate (Picato) in the cutaneous treatment of non-hyperkeratotic, non-hypertrophic actinic keratosis in adults.

Objectives: The objective of this paper is to summarise the scientific review of the application leading to regulatory approval in the EU. The full scientific assessment report and product information, including the summary of product characteristics, are available on the EMA website (www.

Efficient feature selection and classification of protein sequence data in bioinformatics.

Bioinformatics has been an emerging area of research for the last three decades. The ultimate aims of bioinformatics were to store and manage the biological data, and develop and analyze computational tools to enhance their understanding. The size of data accumulated under various sequencing projects is increasing exponentially, which presents difficulties for the experimental methods.

Probing the role of helix α1 in the acid-tolerance and thermal stability of the Streptomyces sp. SK Glucose Isomerase by site-directed mutagenesis.

In order to investigate the role of helix α1 in the different biochemical properties between class I and class II Glucose Isomerases, a histidine and a phenylalanine residue were inserted at position 17 and 19 of Streptomyces sp. SK Glucose Isomerase (SKGI). In addition, W16 was substituted by a histidine.

On the combination of wavelet and curvelet for feature extraction to classify lung cancer on chest radiographs.

This paper investigates the combination of multiresolution methods for feature extraction for lung cancer. The focus is on the impact of combining wavelet and curvelet on the accuracy of the disease diagnosis. The paper investigates feature extraction with two different levels of wavelet, two different wavelet functions and the combination of wavelet and curvelet to obtain a high classification rate.

Development of a novel mathematical model using a group contribution method for prediction of ionic liquid toxicities.

A new mathematical model has been developed that expresses the toxicities (EC₅₀ values) of a wide variety of ionic liquids (ILs) towards the freshwater flea Daphnia magna by means of a quantitative structure-activity relationship (QSAR). The data were analyzed using summed contributions from the cations, their alkyl substituents and anions. The model employed multiple linear regression analysis with polynomial model using the MATLAB software.

Breast cancer diagnosis in digital mammogram using multiscale curvelet transform.

This paper presents an approach for breast cancer diagnosis in digital mammogram using curvelet transform. After decomposing the mammogram images in curvelet basis, a special set of the biggest coefficients is extracted as feature vector. The Euclidean distance is then used to construct a supervised classifier.

[Gastritis cystica polyposa: report of 7 cases and literature review].

Gastritis cystica polyposa (GCP) is a rare inflammatory disease of the gastric remnant that usually develops after partial gastrectomy. It is defined by the presence of polyps on anastomotic gastric mucosa and at histopathological examination, by the presence of mucosal and submucosal cysts with foveolar hyperplasia. The disease is characterized by the frequency of gastro-intestinal bleeding and possibility of carcinomatous association.

[Preliminary results of surgical treatment of developmental dislocation of the hip in older children].

Reduction of developmental dislocation of the hip is difficult to achieve in children after walking age and particularly in older children. In fact, at this age the important retraction of the muscles around the hip associated with a marked acetabular dysplasia and elongation of the joint capsule explain the difficulty and instability of reduction and the frequency of complications. In this study we reviewed retrospectively the clinical and radiological results of 26 developmental dislocations of the hip treated by open reduction, pelvic osteotomy and femoral shortening in 21 children aged more than 5 years.