Publications by authors named "Samin Hong"
Purpose: The Korean Society of Coloproctology has been conducting Colorectal Cancer Awareness Campaign, also known as the Gold Ribbon Campaign, every September since 2007. The 2022 campaign was held through a metaverse platform targeting the younger age group under the slogan of raising awareness of early-onset colorectal cancer (CRC). This study aimed to analyze the impact of the 2022 campaign on a metaverse platform.
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- - The study aimed to identify risk factors for visual field progression in myopic patients suffering from normal-tension glaucoma (NTG) over an observation period of roughly 7 years.
- - Out of 51 patients observed, 16 showed progression, with abnormal retinal nerve fiber layer (RNFL) color codes—especially in the 7 o'clock inferotemporal sector—associated with this progression.
- - The study concluded that thinning of the RNFL in the inferotemporal sector is a significant risk factor for disease progression in NTG patients with myopia.
Article Synopsis
- The study investigated the neuroprotective effects of etanercept, a TNF-α inhibitor, on axonal injury in rats experiencing acute ischemia induced by increased intraocular pressure.
- Rats were treated with etanercept at either 0.3 or 1.0 mg/kg, and results showed a significant increase in the number of preserved axons compared to a control group treated with phosphate-buffered saline (PBS).
- The etanercept-treated groups also exhibited lower levels of microglial activity, indicating a potential for etanercept as a new treatment for neuroprotection in TNF-α-related conditions.
Purpose. To estimate the prevalence of glaucoma and costs associated with glaucoma care in South Korea between 2008 and 2013 using the Korean national claims database. Design.
View Article and Find Full Text PDFAims: To investigate whether tobacco smoke directly injures retinal ganglion cells (RGCs) and to evaluate the mechanisms of cell death.
Methods: Primary rat RGCs were harvested from 3- or 4-day-old newborn rats and exposed to cigarette smoke extract (CSE). Cell viability was determined by adenosine 5'-triphosphate (ATP) assay.
Background: The objective of the study is to examine the effect of trabeculectomy on intraocular lens power calculations in patients with open-angle glaucoma (OAG) undergoing cataract surgery.
Design: The design is retrospective data analysis.
Participants: There are a total of 55 eyes of 55 patients with OAG who had a cataract surgery alone or in combination with trabeculectomy.
Purpose: To evaluate clinical risk factors of disease progression after cataract surgery using phacoemulsification with posterior chamber intraocular lens implantation, in eyes with chronic angle-closure glaucoma (CACG) and coexisting cataract.
Design: Retrospective study.
Methods: The data of 56 eyes of 45 CACG patients who had undergone uncomplicated phacoemulsification with posterior chamber intraocular lens implantation were retrospectively analyzed.
Purpose: To evaluate and compare the frequency, type and cause of imaging artifacts incurred when using swept-source optical coherence tomography (SS OCT) and Cirrus HD OCT in the same patients on the same day.
Materials And Methods: From left eye OCT results of 72 patients, disc area and macular area data could be compared between the two types of OCT. For each scan, the final printout report and source data were examined.
Article Synopsis
- - This study examined the connection between the thickness of the retinal nerve fiber layer (RNFL) and the severity of visual field loss in glaucoma patients using optical coherence tomography (OCT) and standard perimetry tests.
- - The research involved 104 glaucoma patients and 59 healthy subjects, measuring RNFL thickness with two types of OCT and comparing it to four different visual field severity indices.
- - Results showed a moderate correlation between RNFL thickness and visual field severity, with the inferior RNFL showing the strongest relationship across all indices, while no significant differences were found based on the type of OCT used or the severity index applied.
Purpose: To increase the effectiveness of treating open-angle glaucoma (OAG), we tried to find a screening method of differentiating OAG from glaucoma suspect (GS) without a visual field (VF) test.
Methods: Data were collected from the Korean National Health and Nutrition Examination Survey (KNHANES) conducted in 2010. Of 8958 participants, 386 suspected OAG subjects underwent a VF test.
Background: Brimonidine is a highly selective α2 adrenergic agonist that has been widely used in anti-glaucoma eyedrops. The aim of this study was to investigate its putative anti-fibrotic role in the fibrosis caused by activated Tenon's fibroblasts.
Methods: Primary cultured human Tenon's fibroblasts were exposed to 2.
Article Synopsis
- * Preoperative intraocular pressure was similar in both groups, and after 48 months, the average pressures remained close, with trabeculectomy showing slightly better success rates at both 12 and 48 months.
- * Despite similarities in overall effectiveness, trabeculectomy had a higher complication rate, including serious issues like postoperative endophthalmitis.
Article Synopsis
- The study aimed to compare the effectiveness of three imaging methods for detecting defects in the retinal nerve fiber layer (RNFL) in different patient groups, including normal, glaucoma suspects, and glaucoma patients.
- Researchers utilized 300 images rated by five independent evaluators, analyzing factors like agreement levels among raters and the methods' sensitivity and specificity.
- Results indicated that blue reflectance RNFL photography with confocal scanning laser ophthalmoscopy (CSLO) outperformed the other methods, particularly in identifying wedge defects and advanced glaucoma cases.
The neuroprotective effect of maltol against oxidative stress on rat retinal neuronal cells.
Korean J Ophthalmol
February 2015
Purpose: Maltol (3-hydroxy-2-methyl-4-pyrone), formed by the thermal degradation of starch, is found in coffee, caramelized foods, and Korean ginseng root. This study investigated whether maltol could rescue neuroretinal cells from oxidative injury in vitro.
Methods: R28 cells, which are rat embryonic precursor neuroretinal cells, were exposed to hydrogen peroxide (H2O2, 0.
Purpose: To investigate whether retinal nerve fiber layer (RNFL) thickness is decreased in patients with hematologic malignancy using optical coherence tomography (OCT).
Patients And Methods: This prospective, observational cross-sectional study included 65 eyes from 34 patients with hematologic malignancy and 72 healthy control eyes. OCT-measured RNFL thickness parameters (average, 4 quadrants, and 12 clock-hour thickness) and RNFL defect in red-free photo were compared between patients with hematologic malignancy and controls.
Background: Many patients with glaucoma have difficulty using antiglaucoma eye drops because of dry eye symptom. In this prospective, randomized, double-blind, placebo-controlled study, we evaluated the effect of Korean Red Ginseng on dry eye syndrome in patients with glaucoma treated with antiglaucoma eye drops.
Methods: Forty-nine participants were allocated to the Korean Red Ginseng (3 g/day; n = 24) or placebo (n = 25) groups for 8 weeks.
Purpose: To evaluate and compare the efficacy and safety of combined phacoemulsification and goniosynechialysis (PEGS) to phacoemulsification alone (PE) in patients with medically well-controlled chronic angle-closure glaucoma (CACG) with cataracts.
Materials: Thirty eyes diagnosed with CACG and requiring cataract surgery from January 2008 to October 2010 were prospectively randomized, 15 each to PE and PEGS. Changes in peripheral anterior synechiae (PAS), intraocular pressure (IOP), anterior chamber depth, and number of antiglaucoma drugs from baseline to 2 months after the operation were analyzed, as were the type and number of complications.
Background: Elevated intraocular pressure (IOP) is a major risk factor for the development and/or progression of glaucoma, and a large diurnal IOP fluctuation has been identified as an independent risk factor of glaucoma progression. However, most previous studies have not considered the repeatability of 24-hour IOP measurements. The aim of this study was to evaluate the instability of 24-hour IOP fluctuations in healthy young subjects.
View Article and Find Full Text PDFPurpose: To evaluate the neuroprotective and neurite outgrowth effects of maltol, a natural aroma compound, on retinal ganglion cells (RGCs) under oxidative stress in vitro.
Methods: Mouse primary RGCs were isolated using immunopanning-magnetic separation and exposed to H2O2 in the presence of maltol. The cell viability and apoptosis were determined by using adenosine 5'-triphosphate (ATP) assay and terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL), respectively.
Purpose: To evaluate the clinical performance of visual field (VF) tests and optical coherence tomography (OCT) in diagnosing glaucoma.
Methods: One hundred sets of disc photographs, red-free fundus photographs, VF tests, and OCT images were presented progressively to seven ophthalmologists. Each set was provided in three steps: (1) the disc and red-free fundus photographs were shown first; (2) then, VF tests were also provided; and (3) finally, the OCT results were provided.
Purpose: Normal-tension glaucoma (NTG) is a heterogenous disease, and there is still controversy about subclassifications of this disorder. On the basis of spectral-domain optical coherence tomography (SD-OCT), we subdivided NTG with hierarchical cluster analysis using optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thicknesses.
Patients And Methods: A total of 200 eyes of 200 NTG patients between March 2011 and June 2012 underwent SD-OCT scans to measure ONH parameters and RNFL thicknesses.
Background/aims: Systemic hypertension is thought to increase the risk for developing open-angle glaucoma (OAG) through several mechanisms. However, previous epidemiological studies have shown conflicting results regarding this potential association. We systematically evaluated this issue by conducting a meta-analysis of population-based studies.
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