Publications by authors named "Samil Park"

Background: Current guidelines for chronic hepatitis B recommend antiviral therapy for individuals with non-cirrhotic chronic hepatitis B only if they have significant liver fibrosis or elevated alanine aminotransferase (ALT) concentrations. We aimed to assess the efficacy of early antiviral treatment in preventing serious liver-related adverse events in individuals with non-cirrhotic chronic hepatitis B and moderate or high viraemia but normal or mildly elevated ALT concentrations.

Methods: ATTENTION is an ongoing randomised controlled trial being conducted at 22 centres in South Korea and Taiwan.

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Background & Aims: Various hepatocellular carcinoma (HCC) prediction models have been proposed for patients with chronic hepatitis B (CHB) using clinical variables. We aimed to develop an artificial intelligence (AI)-based HCC prediction model by incorporating imaging biomarkers derived from abdominal computed tomography (CT) images along with clinical variables.

Methods: An AI prediction model employing a gradient-boosting machine algorithm was developed utilizing imaging biomarkers extracted by DeepFore, a deep learning-based CT auto-segmentation software.

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Idiopathic pulmonary fibrosis (IPF) is a pulmonary disease characterized by excessive extracellular matrix protein deposition in the lung interstitium, subsequently causing respiratory failure. IPF still has a high medical unmet requirement due to the lack of effective treatments to inhibit disease progression. The etiology of IPF remains unclear, but mitochondrial dysfunction is considered to be associated with IPF development.

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Article Synopsis
  • - This study examines the link between Moyamoya disease (MMD) and open-angle glaucoma (OAG) using data from 36,432 MMD patients and 346,769 matched controls in South Korea from 2002 to 2022.
  • - Researchers used statistical models to find that patients with MMD had a significantly higher risk of developing OAG compared to those without MMD, with a hazard ratio of 1.26.
  • - The cumulative incidence of OAG was 3.7% in the MMD group versus 2.9% in the control group, indicating that MMD patients consistently faced a greater risk of developing OAG throughout the study.
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  • - The study aimed to explore the risk of retinal vascular occlusion in patients with Moyamoya disease (MMD) using data from a large national health insurance database in Korea.
  • - Researchers analyzed over 34,000 newly diagnosed MMD patients and matched them with control subjects to investigate the occurrence of retinal vascular occlusion events through specific diagnostic codes.
  • - Results indicated that MMD patients had a significantly higher risk of developing retinal vascular occlusion, with particular concern for central retinal artery occlusion, highlighting MMD as a notable risk factor for this condition.
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  • - The study aimed to evaluate the reliability and validity of the Korean version of the SCales for Outcomes in Parkinson's Disease-Cognition (K-SCOPA-Cog) for assessing cognition in Parkinson's disease patients in South Korea.
  • - A total of 129 patients participated, and various statistical methods, including Cronbach's alpha and Spearman’s rank correlation, were employed to test the reliability and concurrent validity against established cognitive assessments.
  • - Results showed that the K-SCOPA-Cog has strong reliability (Cronbach's alpha of 0.797, ICC of 0.887) and a significant correlation with other cognitive measures (MOCA-K and K-MMSE), indicating it is a valid tool for cognitive assessment in this
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Coronavirus disease 2019 (COVID-19) vaccination may non-specifically alter the host immune system. This study aimed to evaluate the effect of COVID-19 vaccination on hepatitis B surface Ag (HBsAg) titer and host immunity in chronic hepatitis B (CHB) patients. Consecutive 2,797 CHB patients who had serial HBsAg measurements during antiviral treatment were included in this study.

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Article Synopsis
  • The study investigates how pretreatment HBV DNA levels affect outcomes after stopping nucleotide analogue (NUC) therapy for chronic hepatitis B.
  • Data were collected from 757 HBeAg-negative patients predominantly from Asia, analyzing their relapse rates and chances of HBsAg loss based on their HBV DNA levels before treatment.
  • Results show that lower pretreatment HBV DNA (<20,000 IU/ml) significantly decreases the risk of clinical relapse and increases the likelihood of HBsAg loss, indicating that some patients may not need retreatment after NUC cessation.
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Background/aims: Despite the availability of direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection in Korea, need remains for pangenotypic regimens that can be used in the presence of hepatic impairment, comorbidities, or prior treatment failure. We investigated the efficacy and safety of sofosbuvir-velpatasvir and sofosbuvir-velpatasvir-voxilaprevir for 12 weeks in HCV-infected Korean adults.

Methods: This Phase 3b, multicenter, open-label study included 2 cohorts.

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Purpose: We report the estimated incidence of, and risk factors for, recurrent anterior uveitis in patients with initial acute-onset Vogt-Koyanagi-Harada (VKH) disease using survival analyses.

Methods: Patients who were diagnosed with initial acute-onset VKH disease during 2003-2022 at two university hospitals were included. Recurrent anterior uveitis was defined as the first occurrence of the granulomatous anterior uveitis with anterior chamber cells and flare of 2+ or more by the Standardization of Uveitis Nomenclature (SUN) Working Group grading scheme, after the disappearance of conspicuous uveitis and serous retinal detachment for at least 3 months, regardless of systemic or local treatment.

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  • Chronic hepatitis B (CHB) can increase the risk of a type of cancer called non-Hodgkin lymphoma (NHL).
  • This study looked at two groups of lymphoma patients: those with CHB who got antiviral treatment and those without CHB.
  • Results showed that CHB patients who received antiviral treatment lived longer and had better progress in their cancer treatment compared to those without hepatitis B.
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Background: Over the last few decades, there has been growing evidence of earlier onset and progression of puberty worldwide. This population-based longitudinal cohort study aimed to analyze the change in the annual incidence rate of central precocious puberty (CPP) among Korean children over the most recent decade, using the national registry data.

Method: The International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) and insurance claims for gonadotropin-releasing hormone agonist (GnRHa) treatment were used to identify CPP patients who were using the Korean Health Insurance Review & Assessment Service (HIRA) database between 2008 and 2020.

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Introduction: Although transarterial radioembolization (TARE) using yttrium-90 (Y) is a treatment option for large hepatocellular carcinoma (HCC), a fraction of patients are ineligible for TARE due to high lung shunt fraction (LSF).

Methods: We evaluated if treatment with transarterial chemoembolization (TACE), owing to TARE ineligibility was associated with early HCC progression. Consecutive patients with HCC who were initially TARE candidates were included.

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Phytoremediation of metals from water (WM) and nutrient (NM) media exposed to waste metal cutting fluid (WMCF) along with temperature (T) and humidity (H) stress was tested using Azolla imbricata (Roxb.) Nakai. In the absence of WMCF, biomass was higher in NM than in WM during all tests.

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Early successes in controlling the COVID-19 pandemic have prevented Republic of Korea from implementing a prompt, large-scale vaccine rollout to the public. The influence of traditional media on public opinion remains critical and substantial in Republic of Korea, and there have been heated debates about vaccination in traditional media reports in Korea. Effective and efficient public health communication is integral in managing public health challenges.

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Mitochondria are organelles that play a vital role in cellular survival by supplying ATP and metabolic substrates via oxidative phosphorylation and the Krebs cycle. Hence, mitochondrial dysfunction contributes to many human diseases, including metabolic syndromes, neurodegenerative diseases, cancer, and aging. Mitochondrial transfer between cells has been shown to occur naturally, and mitochondrial transplantation is beneficial for treating mitochondrial dysfunction.

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Objective: To investigate the long-term clinical outcomes of pallidal deep brain stimulation (GPi-DBS) in patients with pantothenate kinase-associated neurodegeneration (PKAN).

Methods: We reviewed the records of patients with genetically confirmed PKAN who received bilateral GPi-DBS for refractory dystonia and were clinically followed up for at least 2 years postoperatively at two centers in Korea. Pre- and postoperative Burke- Fahn-Marsden Dystonia Rating Scale motor subscale (BFMDRS-M) scores, disability subscale (BFMDRS-D) scores, and qualitative clinical information were prospectively collected.

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It remains controversial whether surgical resection, compared to radiofrequency ablation (RFA), improves overall survival (OS) in patients with early hepatocellular carcinoma (HCC). This study aimed to compare OS after RFA with that after resection for HCC. This retrospective study included patients who underwent RFA or surgical resection as initial treatment for hepatitis B virus (HBV)-related HCC at a very early or early stage.

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Background & Aims: Several models have recently been developed to predict risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Our aims were to develop and validate an artificial intelligence-assisted prediction model of HCC risk.

Methods: Using a gradient-boosting machine (GBM) algorithm, a model was developed using 6,051 patients with CHB who received entecavir or tenofovir therapy from 4 hospitals in Korea.

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Background: Still in real-world practice, advanced hepatocellular carcinoma (HCC) patients are treated with transarterial chemoembolization (TACE). This study compared the therapeutic effectiveness of initial TACE treatment and initial sorafenib treatment in advanced HCC patients.

Patient And Methods: Advanced HCC patients initially treated with sorafenib or TACE were included in this study.

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Background And Aims: Clinical evidence for the benefits of branched-chain amino acids (BCAAs) is lacking in advanced liver disease. We evaluated the potential benefits of long-term oral BCAA supplementation in patients with advanced liver disease.

Methods: Liver cirrhosis patients with Child-Pugh (CP) scores from 8 to 10 were prospectively recruited from 13 medical centers.

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  • - Impulse-control disorder, a significant nonmotor symptom of Parkinson's disease (PD), can negatively impact patients' financial and social well-being, leading to a poorer quality of life; the study aimed to validate the Korean Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease Rating Scale (K-QUIP-RS).
  • - A total of 136 PD patients were recruited from various clinics to complete the K-QUIP-RS and other assessments measuring motor symptoms, nonmotor statuses, and quality of life; results showed strong internal consistency and test-retest reliability for the K-QUIP-RS.
  • - The K-QUIP-RS scores correlated positively with indicators of depression, motivation,
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Objective: Direct comparison of the clinical outcomes between nucleos(t)ide analogue (NA) discontinuation versus NA continuation has not been performed in patients with chronic hepatitis B who achieved HBsAg-seroclearance. Whether NA discontinuation was as safe as NA continuation after NA-induced surface antigen of HBV (HBsAg) seroclearance was investigated in the present study.

Designs: This multicentre study included 276 patients from 16 hospitals in Korea who achieved NA-induced HBsAg seroclearance: 131 (47.

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Background And Purpose: This study aimed to determine the clinimetric properties of the Korean version of Parkinson's Disease Sleep Scale-2 (K-PDSS-2) and whether distinct subtypes of sleep disturbance can be empirically identified in patients with Parkinson's disease (PD) using the cross-culturally validated K-PDSS-2.

Methods: The internal consistency, test-retest reliability, scale precision, and convergent validity of K-PDSS-2 were assessed in a nationwide, multicenter study of 122 patients with PD. Latent class analysis (LCA) was used to derive subgroups of patients who experienced similar patterns of sleep-related problems and nocturnal disabilities.

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