Early Orthodontic Treatment Needs of Children in High Caries Population Using Index for Preventive and Interceptive Orthodontic Treatment Needs.

Aim: Early identification and management of developing malocclusion can reduce or eliminate the need for future complicated treatment procedures. The present study was undertaken to assess early orthodontic treatment needs in 6- and 9-year-old children using the index for preventive and interceptive orthodontic treatment need (IPION) in Pune, India.

Materials And Methods: A total of 360 children reporting to the Department of Pediatric and Preventive Dentistry were evaluated clinically and on their respective dental casts according to the IPION requirement.

Influence of Birth Characteristics and Feeding Practices on Eruption of Primary Teeth in Children: A Preliminary Cross-sectional Observational Study.

Background: The eruption process is under strong genetic control, external environmental factors also significantly contribute to this process. Therefore the present study was undertaken to identify the influence of birth characteristics and feeding practices on the eruption of the first primary tooth among healthy children in Pune, Maharashtra, India.

Materials And Methods: The study was undertaken among 200 children aged 3-24 months.

Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha.

Thyroid hormones act in bone and cartilage via thyroid hormone receptor alpha (TRα). In the absence of triiodothyronine (T3), TRα interacts with co-repressors, including nuclear receptor co-repressor-1 (NCoR1), which recruit histone deacetylases (HDACs) and mediate transcriptional repression. Dominant-negative mutations of TRα cause resistance to thyroid hormone alpha (RTHα; OMIM 614450), characterized by excessive repression of T3 target genes leading to delayed skeletal development, growth retardation, and bone dysplasia.