Fascin over expression is associated with dysplastic changes in sinonasal inverted papillomas: a study of 47 cases.

Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility.

Cytology of metastatic appendiceal goblet cell carcinoid in pleural effusion fluid: a case report.

Goblet cell appendiceal carcinoid (GCAC) is a rare neoplasm. We described the case of a 72-year-old man who presented with symptoms related to ascites. A computed tomography (CT) scan showed a mass involving the base of the appendix, ascites and concomitant pleural effusion.

Imaging of the optic disc and retinal nerve fiber layer in acute optic neuritis.

Purpose: To demonstrate whether optical coherence tomography (OCT-3) and scanning laser ophthalmoscopy (HRT-2) can be used to measure changes of the optic disc and peripapillary retinal nerve fiber layer (RNFL) in eyes with acute retrobulbar optic neuritis that have no clinically apparent optic disc swelling. To correlate these findings with presentation magnetic resonance imaging (MRI) of the affected optic nerve.

Methods: Eight consecutive patients with acute retrobulbar optic neuritis, who had no prior optic neuritis in either eye, were prospectively investigated at presentation and at between 1 and 3 months with clinical examination, OCT-3, HRT-2.

Does malaria during pregnancy affect the newborn?

Objective: To investigate the effect of malarial infection during pregnancy on the newborn.

Methods: A retrospective cohort study was conducted at The Aga Khan University Hospital (AKUH), Karachi, using in-patient hospital records over an 11-year period from 1988 to 1999. The incidence of preterm delivery, low birth weight (LBW) and intrauterine growth retardation (IUGR) in 29 pregnant women with malaria, was compared with that in 66 selected pregnant women without malaria, who delivered at the AKUH during the same time period.

Macular and retinal nerve fiber layer thickness measurement reproducibility using optical coherence tomography (OCT-3).

Purpose: To assess the reproducibility of retinal nerve fiber layer thickness and macular thickness measurements using OCT-3.

Methods: Randomly chosen eyes of healthy individuals were scanned following pupillary dilation by two trained operators (RGO, RV) using OCT-3 (software version A1.1, Carl Zeiss Meditec, Inc.

Scanning protocol choice affects optical coherence tomography (OCT-3) measurements.

Purpose: To determine the optimal OCT-3 scanning protocol.

Methods: Normal subjects, ocular hypertensive, and open-angle glaucoma patients were enrolled. The "fast" RNFL scan protocol consists of 3 consecutive circular scans, each containing 256 A-scans obtained in a single 1.

Effect of pupillary dilation on retinal nerve fiber layer thickness measurements using optical coherence tomography.

Purpose: To evaluate the effect of pupillary dilation on retinal nerve fiber layer thickness (RNFL) measurements using optical coherence tomography (OCT-3).

Methods: Randomly chosen eyes of healthy individuals were scanned before and after pupillary dilation by two trained operators (R.G.