Seven-valent pneumococcal conjugate vaccine in pediatric solid organ transplant recipients: a prospective study of safety and immunogenicity.

Objectives: To determine the safety and immunogenicity of the conjugate pneumococcal vaccine (PCV7) in pediatric solid organ transplant recipients.

Patients And Methods: Pediatric solid organ transplant recipients were prospectively enrolled at > or =4 months following transplantation. Eligible pneumococcal vaccine-naive subjects received 3 doses of PCV7 at 8 week intervals, followed 8 weeks later by a dose of the 23-valent vaccine (PV23).

Sustainability of humoral responses to varicella vaccine in pediatric transplant recipients following a pretransplantation immunization strategy.

Varicella infections pose serious challenges for organ transplant recipients. To determine the safety and immunogenicity of the OMVV and determine the maintenance of OMVV responses in transplanted subjects at varying periods of immunosuppression within the first two yr following transplantation. Eligible subjects given a two-dose OMVV pretransplantation were monitored for AE.

Response to a protease-inhibitor (ritonavir)-containing combination antiretroviral regimen in HIV-infected children.

Introduction: The number of antiretroviral agents available for children who are failing existing therapy is limited. Data are lacking on the use of various combination regimens and the resulting viral load dynamics in such children.

Methods: Between March 1998 and March 2000, HIV-infected children younger than 18 years of age were studied in an open trial.

Risk factors for post-transplant lymphoproliferative disorder in pediatric patients: a case-control study.

Post-transplant Lymphoproliferative Disorder (PTLD) because of the Epstein-Barr Virus (EBV) is a major concern after pediatric transplantation. The group at greatest risk is EBV-seronegative recipients who receive EBV-seropositive organs. Additional risk factors remain to be determined, including those among EBV-seropositive recipients.

Serotypes of respiratory tract isolates of Streptococcus pneumoniae from Jamaican children.

Background: Data are lacking on the pneumococcal serotypes present in many developing regions, including the Caribbean. We examined the serotypes of nasopharyngeal (NP) isolates of pneumococci obtained from Jamaican children.

Methods: We obtained NP samples from children seen in the Emergency Department at the Bustamante Children's Hospital.